Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of pineal research
7 (1989), S. 0
ISSN:
1600-079X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Synaptic ribbons (SR) in melatonin-deficient pinealocytes of the C57BIV6J mouse were quantitatively compared to SR in pinealocytes of the rat after β-adrenergic receptor activation by isoproterenol. Two populations of SR comprising synaptic spherules (SRsp) and synaptic rods (SRr) were described in both the mouse and the rat, but species differences existed in the ratio of SRr to SRsp. Isoproterenol caused a significant increase in frequency of SR of the rat but had little or no effect on SR populations in the mouse. It is unlikely that β-adrenergic receptors are absent on mouse pinealocytes or were not activated since isoproterenol elevated plasma renin concentrations indicating activation of β-adrenergic receptors. Furthermore the pineal of both species receives heavy sympathetic input. These findings indicate that the role and regulation of pinealocyte SR are complex and are functionally linked to β-adrenergic receptors as well as other mechanisms related to the production of melatonin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-079X.1989.tb00453.x
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