Electronic Resource
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:
Blackwell Science Inc.
International journal of gynecological cancer
6 (1996), S. 0
ISSN:
1525-1438
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The Prognostic significance of lymphvascular invasion (LVI) in stage: IB cervix cancer remains controversial in spite of several recent reports in this literature. This report analyses the impact of LVI in patients undergoing surgery followed by postoperative radiation therapy.The clinical-pathological records of 110 patients with stage IB carcinoma of the cervix cancer remains controversial in spite of several recent reports in this literature. This report analyses the impact of LVI in patients undergoing surgery followed bu postoperative radiation therapy.sessed for grade, positive margins, depth of invasion, positive nodes, and LVI. Only LVI showed a significant correlation (P = 0.0002) with local failure. Thirty-two patients with squamous cell carcinoma and LVI were identified. Seventeen of these patients received postoperative radiotherapy and 15 patients received no adjuvant therapy. Both groups were traced for outcome. Four of the 15 patients (27%) with LVI treated with surgery alone developed local recurrence, compared to 0/17 patients who received postoperative radiotherapy (P = 0.038). The 5-year and 7-year survival of the entire group was excellent, 97.2% and 94.9% respectively. There was a trend towards significance (P = 0.07) in survival between LVI+ and LVI− patients.Lymphvascular invasion was significantly associated with increased local failure in our analysis. Although prospective randomized trials are in progress to further evaluate this issue there is growing concern about low accrual because of physicians biases regarding this controversial issue. Adjuvant postoperative radiotherapy appears beneficial in improving local control for LVI patients in our study, but its impact on survival is still questionable. We recommend enrollment of patients in a national cooperative trial whenever possible. Treatment of patients off protocol solely for LVI+ is still quite controversial and must be left to the discretion of the clinician.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1525-1438.1996.06030208.x
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