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  • 1
    Electronic Resource
    Electronic Resource
    Monoclonal antibodies against Streptococcus mutans 74 kDa cell wall saliva receptor (74 kDa SR): correlation between antigenic structure and saliva binding sites (1988)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 50 (1988), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Five hybrid cell lines secreting monoclonal antibodies (MAbs; LOSM5, 7, 8, 10 and 11) against Streptococcus mutans serotype f 74-kDa saliva receptor (SR) were generated by fusing rats IR983F myeloma cells with splenocytes from rats immunized with affinity purified 74-kDa SR. All the five MAbs recognized both native and denatured forms of the SR. Three partially different epitopes could be delineated on protein 74-kDa by using unlabeled and alkaline phosphatase-labeled MAbs in competitive enzyme-linked immunosorbent assay (ELISA). Two of them are involved in the binding of salivary glycoproteins to S. mutans cells; as demonstrated by the inhibition of saliva binding to S. mutans cells by the MAbs LOSM7, 8 and 11. The five MAbs also reacted with 150-kDa protein, a higher Mr protein and peptide mapping of 150-kDa and 74-kDa SR showed identical patterns for both polypeptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1988.tb02940.x
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative study of oral conditions in schoolchildren of Strasbourg, France, 1974–85 (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Community dentistry and oral epidemiology 15 (1987), S. 0 
    Details
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract A representative sample of 1650 children randomly selected in the 6–15-yr-old schoolchild population of Strasbourg was examined by well-calibrated examiners. The prevalence of caries was determined with the DMFT, DMFS and dft indices using bitewing radiographs. Plaque, calculus and gingival indices were also determined. The results obtained were compared with the initial study of 1974 performed in Strasbourg using the same epidemiologic methods. Whereas no important variations were observed in caries prevalence of primary teeth, a significant reduction of caries activity was observed in DMFT and DMFS indices in all age groups. There was a reduction of these two indices of respectively 32% and 33% in the 12-yr-old children. The reduction was the most significant on approximal surface lesions. A statistically significant decrease of the calculus and gingival indices was also observed between 1974 and 1984. A less significant decrease was observed for the plaque index.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0528.1987.tb00522.x
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  • 3
    Electronic Resource
    Electronic Resource
    Dental caries and oral hygiene among 12-year-old children in Martinique, France (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Community dentistry and oral epidemiology 19 (1991), S. 0 
    Details
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0528.1991.tb00107.x
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  • 4
    Electronic Resource
    Electronic Resource
    Electron microscopic study of the regeneration of cementum and periodontal connective tissue attachment in the cat (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 15 (1980), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Regeneration of periodontal connective tissue attachment was studied at the ultrastructural level in cats following the removal of cementum and superficial dentin through a surgically created fenestration in the facial alveolar plate. Non-decalcified specimens were examined 33, 45, 70, and 105 days after surgery. In early stages of healing, fibroblasts were aligned parallel, and immediately adjacent, to the cut, irregular dentin surface; subsequently, collagenous matrix formation was observed at this site. Some regions of the defects showed surface demineralization and extension of collagen into dentinal tubules. The first indication of cementum mineralization was the deposition of small crystallites along the irregularities of the dentin surface. After further development, a well-defined zone containing c1osel packed crystallites was usually evident at the new dentin-cementum junction. Peripheral to this, collagen orientation in the calcified cementum was primarily parallel to the tooth surface, with some perpendicular orientation suggestive of Sharpey's fiber formation. Collagen-mineral patterns typical of the normal cementum surface were observed, and cementoblasts were seen in various stages of inclusion into the calcified matrix. Where the injury had not reached the dentin, collagen fibrils of new and old cementum were interwoven, and the junctional region demonstrated incomplete mineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1980.tb00261.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mise en évidence de corps multivésiculaires intranucléaires au niveau des odontoblastes jeunes (1969)
    Springer
    Cell & tissue research 95 (1969), S. 310-316 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Des corps niultivésiculaires, limités par une membrane lisse et contenant une trentaine de vésicules, ont pu être observés dans le noyau d'odontoblastes de chats nouveaunés. Une fusion de la membrane périphérique des corps multivésiculaires avec la membrane nucléaire interne est suivie du passage des vésicules dans la citerne périnucléaire, dans la lumière ergastoplasmique et finalement d'ans l'espace intercellulaire des odontoblastes, située à la hauteur des noyaux.
    Notes: Summary Multivesicular bodies, surrounded by a smooth membrane and containing about thirty vesicles, have been observed in the nucleus of young odontoblasts in new-born cats. A fusion of the limiting membrane of the multivesicular bodies with the inner nuclear membrane is followed by the passage of the vesicles in the perinuclear cisterna, the endoplasmic reticulum and finally the intercellular odontoblastic space, at the level of the nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968460
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  • 6
    Electronic Resource
    Electronic Resource
    Sterische Effekte bei endo, exo-Tetracyclo[6.2.1.13,6.02,7]-dodecanen: Einfluß von 4-Substituenten auf die Solvolyse der 11-epimeren Sulfonate1) (1981)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3336-3348 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Steric Effects in endo, exo-tetracyclo [6.2.1.1.3,602,7]dodecanes: Influence of 4-Substituents on the Solvolysis of Epimeric 11-Sulfonates1)By stereoselective additions of 11-anti-acetoxy-endo,exo-tetracyclo[6.2.1.13,6.02,7]dodec-4-ene (12a) compounds 6, 13-18 have been Prepared. Olefin 19, obtained by Wittig reaction from 17, was hydrogenated yielding methyl compound 9b. Reduction of the keto group of 16 gives the 11-syn alkohol 11a. Rates of solvolysis of sulfonates 5b,c, 6b, 7b, 8b, 9c, 10c, and 11b have been determined in 60% acetone. Rates of tosylates 2b-anti, 5e, and 9d in acetic acid can be correlated by the calculated difference of strain energy (hydrocarbon-cation). syn-Sulfonates 8b and 11b react ca. 103 times faster than the anti-isomers 5c and 9c. - Isomerisation of “inside” -epimers 26 and 29 to the “outside”-compounds 28 and 31 cannot be achieved due to the outside attack.
    Notes: Durch stereoselektive Additionsreaktionen an die Doppelbindung von 11-anti-Acetoxy-endo,exo-tetracyclo [6.2.1.13,6.02,7]dodec-4-en (12a) wurden die Verbindungen 6, 13-18 hergestellt. Das Olefin 19 wird durch Wittig-Reaktion aus dem Keton 17 erhalten, es läßt sich katalytisch zur Methylverbindung 9b hydrieren. Reduktion der Ketogruppe in 16 mit LiAlH4 ergibt die 11-syn-Verbindung 11a. - Die Solvolysegeschwindigkeit der Sulfonate 5b,c, 6b, 7b, 8b, 9c, 10c und 11b in 60proz. Aceton/Wasser wird bestimmt. Die Solvolysegeschwindigkeiten der Verbindungen 2b-anti, 5e und 9d in Eisessig lassen sich mit der berechneten Spannungsenergiedifferenz (Kohlenwasserstoff-Kation) korrelieren. Die syn-Sulfonate 8b und 11b reagieren ca. 103 mal schneller als ihre anti-Isomeren 5c und 9c.- Die Isomerisierung der “inside”-Epimeren 26 und 29 zu den entsprechenden “outside”-Verbindungen 28 und 31 wird infolge des stereoselektiven “outside”-Angriffs Verhindert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19811141014
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  • 7
    Electronic Resource
    Electronic Resource
    Polar effects of 4-substituents in the solvolysis of tetracyclo[6.2.1.13,6.02,7]dodecan-11-yl triflates. Through-space vs. inductive model (1985)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 118 (1985), S. 753-763 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Polare Effekte von 4-Substituenten bei der Solvolyse von Tetracyclo[6.2.1.13,6.02,7]dodecan-11-yl-triflaten. Through-space-Effekt im Vergleich zum induktiven Effekt4-Substituierte Tetracyclo[6.2.1.13,6.02,7]dodecan-11-yl derivate 7 wurden ausgehend von den entsprechenden Olefinen 8a-c dargestellt. Die Solvolyse des 11-Triflats der unsubstituierten Ver-bindung sowie die von fünf C-4-substituierten Triflaten (X = CH3, F, OAc, SC6H5 und OCH3) wurde in 60proz. wäßrigem Aceton und in 97 proz. Hexafluorisopropylalkohol (HFIP) untersucht. Die Ergebnisse werden mit denen der bekannten aliphatischen Systeme wie 1, 2 und 3 verglichen. Die Bedeutung von through-space-im Vergleich zu induktiven Effekten wird diskutiert. Die Übertragung polarer Effekte bei der Verbindungsreihe 7 kann mit beiden Modellen beschrieben werden.
    Notes: 4-Substituted tetracyclo[6.2.1.13,6.02,7]dodecan-11-yl derivatives 7 were obtained starting from the corresponding derivatives 8a-c. Solvolyses of the 11-triflate of the parent compound and of five triflates with substitutents at C-4 (X = CH3, F, OAc, SC6H5, and OCH3) were studied in 60% aq. acetone and in 97% hexafluoroisopropyl alcohol (HFIP). Results are compared with those obtained for other aliphatic systems like 1,2, and 3. The relative importance of through-space and inductive effects is discussed. Transmission of polar effects in 7 can be explained by either model.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19851180234
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  • 8
    Electronic Resource
    Electronic Resource
    Sterisch gehinderte Olefine, VII. Dehydratisierung von aliphatischen Di-tert-butylalkylcarbinolen. Kraftfeld-Rechnungen von sterisch gehinderten Ethylenen (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 2636-2647 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Sterically Hindered Olefins, VII. Dehydration of Aliphatic Di-tert-butylalkylcarbinols. Force-Field Calculations of Highly Hindered EthylenesThe tertiary carbinols 1-3 are prepared from the corresponding methyl esters and tert-butyllithium. Dehydration is achieved by treatment with SOCl2 in pyridine and with basic Al2O3. From carbinol 3 the olefine 6 is formed in low yield while 1 and 2 show 1,3-elimination yielding the rearranged olefines 8 and 11, respectively. Methyl 1-Methyl-2-adamantanecarboxylate (17) reacts with tert-butyllithium to the ketone 18 exclusively. - Force-field calculations have been performed on a number of highly substituted olefines using Allingers MMI program. For tetra-tert-butylethylene (22) a strain energy of 100.0 kcal/mol and a torsion angle of 45.1° is calculated. The geometry of syn-fenchylidenefenchane (27) is calculated and compared with the values determined by x-ray structural analysis.
    Notes: Die Dehydratisierung der tertiären Carbinole 1-3 mit SOCl2 in Pyridin und an basischem Al2O3 wird untersucht. Nur beim Adamantylcarbinol 3 wird β-Eliminierung zu (Di-tert-butylmethylen)-adamantan (6) beobachtet; 1 und 2 ergeben 1,3-Eliminierung sowie die umgelagerten Olefine 8 und 11. 1-Methyl-2-adamantancarbonsäure-methylester (17) setzt sich mit tert-Butyllithium ausschließlich zum Keton 18 um. - Von einer Reihe hochsubstituierter Ethylene werden Kraftfeld-Rechnungen mit dem Allinger-Programm (MMI) durchgeführt. Für das hypothetische Tetra-tert-butylethylen (22) wird eine Spannungsenergie von 100.0 kcal/mol und ein Verdrillungswinkel von 45.1° berechnet, außerdem wird die aus der Röntgenstruktur ermittelte Geometrie des syn-Fenchylidenfenchans (27) mit der berechneten verglichen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801130807
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  • 9
    Electronic Resource
    Electronic Resource
    Ergebnisse nichtbindender Wechselwirkungen, II. Notiz zur Umlagerung der isomeren Tetracyclo[6.2.1.13,6.02,7]dodecane (1980)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1980 (1980), S. 650-652 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Results of Nonbonded Interactions, II1).  -  Note on the Rearrangement of Isomeric Tetracyclo-[6.2.1.13,6.02,7]dodecanesThe endo-endo-chloride 1b can be rearranged to the endo-exo-chloride 2b with AlCl3 in CCl4. endo-exo-Chloride 2c is converted into 97% chloride 3b and 3% 2c.
    Notes: Das endo-endo-Chlorid 1b läßt sich mit AlCl3 in CCl4 quantitativ in 2b umlagern; das exo-endo-Chlorid 2c ergibt unter diesen Bedingungen eine Mischung von 97% Umlagerungsprodukt 3b und 3% 2c.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198019800416
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  • 10
    Electronic Resource
    Electronic Resource
    Synthese der epimeren 4-Methyl-Derivate von endo-endo- und exo-endo-Tetracyclo[6.2.1.13,6.02,7]dodecanErgebnisse nichtbindender Wechselwirkungen, 1. Mitteilung. Diese Arbeit wurde von der Deutschen Forschungsgemeinschaft unterstützt. (1980)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 92 (1980), S. 306-307 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19800920413
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