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  • 1
    Electronic Resource
    Electronic Resource
    The association of ATR protein with mouse meiotic chromosome cores (1999)
    Springer
    Chromosoma 108 (1999), S. 95-102 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract.  The ATR (ataxia telangiectasia- and RAD3-related) protein is present on meiotic prophase chromosome cores and paired cores (synaptonemal complexes, SCs). Its striking characteristic is that the protein forms dense aggregates on the cores and SCs of the last chromosomes to pair at the zygotene-pachytene transition. It would appear that the ATR protein either signals delays in pairing or it is directly involved in the completion of the pairing phase. Atm-deficient spermatocytes, which are defective in the chromosome pairing phase, accumulate large amounts of ATR. The behaviour of ATR at meiotic prophase sets it apart from the distribution of the RAD51/DMC1 recombinase complex and our electron microscope observations confirm that they do not co-localize. We failed to detect ATM in association with cores/SCs and we have reported elsewhere that RAD1 protein does not co-localize with DMC1 foci. The expectation that putative DNA-damage checkpoint proteins, ATR, ATM and RAD1, are associated with RAD51/DMC1 recombination sites where DNA breaks are expected to be present, is therefore not supported by our observations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004120050356
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  • 2
    Electronic Resource
    Electronic Resource
    Carbon-13 NMR study of (20,24)-epoxydammarane triterpenes (1984)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 22 (1984), S. 34-38 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Assignments of the 13C NMR signals of the dammarane triterpenes, 3β,25,30-trihydroxy-(20R,24R)-epoxydammaran-16-one 3,30-diacetate (trevoagenin A diacetate) (2), its 20S-isomer (trevoagenin B diacetate) (3) and their related (20R)-3β,30-diacetoxy-16-oxo-25,26,27-trisnordammarane-24,20-lactone (4) and its 20S-isomer (5) have been achieved. Suitable tetrahydrofuran models have been synthesized in order to aid the 13C NMR assignments of the side-chain carbons of the above-mentioned compounds. The remarkable chemical shift differences observed for C-21 and C-22 between each pair of the C-20 epimers (2, 3 and 4, 5) allowed the confirmation of the C-20 stereochemistry of these ocotillol-type dammarane triterpenes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270220108
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    Paper (German National Licenses)
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