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  • 1
    Electronic Resource
    Electronic Resource
    Iso-immune neonatal neutropenia due to an anti-Fc receptor III (CD16) antibody (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 438-441 
    Details
    ISSN: 1432-1076
    Keywords: Neonatal neutropenia ; Iso-immune neutropenia ; Anti-neutrophil antibody ; CD16 molecule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of transient neonatal neutropenia due to a maternal iso-immunization against a non polymorphic region of the glycosylphosphatidylinositollinked Fc receptor type III (CD16) on granulocytes. The mother's granulocytes were typed NA1-negative, NA2-negative and CD16-negative with human and monoclonal antibodies whereas her lymphocytes express the CD16 molecule. Expression of other markers were comparable to the controls. Flow cytometric analysis showed that maternal antibody recognized the granulocytes but not the lymphocytes from blood bank donors and that its binding was decreased on normal, phospholipase C-treated, granulocytes. The binding of commercial CD16 monoclonal antibodies was also dramatically decreased on normal granulocytes pre-incubated with maternal serum. The CD16 specificity of the antibody was confirmed by negative reactions with another CD16-deficient granulocytes. This observation leads us to conclude that celllineage specific differences of CD16 molecules are recognized by the patient's antibody. Moreover, we confirm that the absence of the FcRIII (CD16) on granulocytes is not associated with any pathology or susceptibility to infections and that, in the children, the blockade of this receptor by the maternal antibody only led to moderate neutropenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959359
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  • 2
    Electronic Resource
    Electronic Resource
    The use of cytokines in the treatment of solid tumours (1997)
    Springer
    Hematology and cell therapy 39 (1997), S. 105-108 
    Details
    ISSN: 1279-8509
    Keywords: Cytokine ; Immunothérapy ; Cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This manuscript reviews the clinical triais with cytokines in solid tumors. Starting with Interleukin 2 alone or in association with other cytokines and chemotherapy, the reviews opens the prospects of future directions for the use of cytokines as adjuvant therapy, for vaccination or to inhibit the growth activity of certain cytokines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00282-997-0105-5
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  • 3
    Electronic Resource
    Electronic Resource
    PUBLIC H-2 SPECIFICITIES ARE TARGET DETERMINANTS FOR ALLOREACTIVE CYTOTOXIC T LYMPHOCYTES (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The specificity of he corss-killing exerted by cytotoxic T lymphocytes (CTL's) generated against H-2 region products was investigated in a 51Cr release assay on a panel of target cells from a number of different H-2 haplotypes.Their pattern of reaction shows that: (1) The target cells, expressing public specificities (H-2.28, H-2.1, H-2.5, H-2.3 or H-2.8) which should, theoretically, be recognized by the CTL's were killed, while those expressing no public specificities, recognized according to the H-2 chart by the CTL's wer not killed. (2) The CTL's generated against the H-2.28 specificity expressed on the D region products cross react with target cells expressing this specificity in their K region products and vice versa. The same phenomenon was observed with the H-2.1 specificity. These results provide evidence that public specificities are targets for CTL's. Antiserum reacting against the public specificity recognized by the CTL's was found to block the cross-killing, however, to the same extent as antisera directed against any specificity recognized by the CTL's was found to block the cross-killing, however, to the same extent as antisera directed against any specificity (private or public) expressed on the same molecule as the target determinant. Finally both the inhibition studies using anti-H-2 antisera and the direct cytotoxic assays showed that the public specificities of the H-2.28 family carried by the H-2.D and H-2.L molecules were recognized by different subpopulations of CTL's.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00713.x
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  • 4
    Electronic Resource
    Electronic Resource
    Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG (1992)
    [s.l.] : Nature Publishing Group
    Nature 358 (1992), S. 337-341 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TABLE 1 cDNA sequence and FcyR expression in IIA1.6-transfected cells cDNA Sequence Transfectant cells Number of receptors per cell (xlO4) /Sell FcyRIII (a,y2) 2.8 4 FcyRIII (act4,y2) 1.4 Fc-yRllb2 KKKQVPNPPDLEEAAKTEAENTITYSLLKHPEALDEETEHDYQNHI ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/358337a0
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  • 5
    Electronic Resource
    Electronic Resource
    Human virus-infected target cells lacking HLA antigens resist specific T-lymphocyte cytolysis (1977)
    [s.l.] : Nature Publishing Group
    Nature 269 (1977), S. 806-808 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experiments involved a 51Cr release assay according to Cerottini and Brunner15 with minor modifications. Targets were cells from several B-lymphoblastoid lines and effectors were peripheral T lymphocytes from patients with infectious mononucleosis. The EBV genome-carrying lines used were T-51 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/269806a0
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  • 6
    Electronic Resource
    Electronic Resource
    Stimulation of Lymphocytes by Autologous Leukaemic Cells in Acute Leukaemia (1969)
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 277-279 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The leucoblasts were taken before any transfusion or treatment and isolated in sterile conditions from defibrinated blood in the presence of fluid gelatine10. Suspensions containing more than 90 per cent leucoblasts and a few erythrocytes were frozen slowly in the presence of 10 per cent ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/224277a0
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  • 7
    Electronic Resource
    Electronic Resource
    Correlation between soluble serum CD16 (sCD16) levels and disease stage in patients with multiple myeloma (1993)
    Springer
    Journal of clinical immunology 13 (1993), S. 41-48 
    Details
    ISSN: 1573-2592
    Keywords: IgG-specific Fc receptor type III (FcγRIII) ; CD16 ; prognostic markers ; myeloma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CD16, the type III receptor for IgG, is expressed on neutrophils, natural killer cells, and some T lymphocytes, mast cells, and activated monocytes but not on cells of the B-lymphocyte lineage including plasma cells. It is also produced in a soluble form found in serum. We analyzed sera from 165 multiple-myeloma patients, 29 patients with monoclonal gammopathies of unknown significance, and 20 normal disease-free donors. We found that the level of soluble CD16 was significantly decreased in sera from patients with multiple myeloma compared to sera from healthy and monoclonal gammopathies of unknown significance donors (P=0.0001). In addition, a stage-dependent decrease in soluble CD16 was observed, with a highly significant difference (P=0.004) between stage I and stage II+III myeloma patients. The correlation between the myeloma stage and the serum level of soluble CD16, which is related to the host response, was found to be more sensitive than that of β2-microglobulin, which reflects the tumor burden. The concomitant evaluation of the serum levels of these two markers allows better staging and therefore has a more precise prognostic value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00920634
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