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  • 1
    Electronic Resource
    Electronic Resource
    Diagnosis of malignancy in thyroid nodules by factor analysis of spectral and dynamic structures: a simultaneous dual-isotope dynamic study with thallium-201 and iodine-131 (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 517-521 
    Details
    ISSN: 1619-7089
    Keywords: Dual-isotope studies ; Factor analysis ; Thallium thyroid uptake ; Thyroid nodule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to identify malignant thyroid nodules using iodine-123 and thallium-201 simultaneous dynamic acquisition. The image sequences acquired were processed by factor analysis of spectral and dynamic structures (FASDS). Some 49 patients were investigated, and their diagnoses were confirmed by histological examination. Data processing enables the estimation of the spectra of the two isotopes and the evaluation of the kinetics and spatial structures related to each tracer. The superimposition of thallium and iodide sum images allowed us to delineate the nodule accurately. Two groups were defined: 21 patients who had 201T1 uptake in the nodule, and 28 who had none. In the first group, 5 nodules were carcinomas, whereas all nodules in the second group were benign. The results of the 201T1 dynamic study improved the diagnosis of carcinoma as the number of false-positive cases decreased. FASDS succeeds in extracting spectral and kinetic information, proving its usefulness in clinical diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185858
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Factor analysis as a means of determining response to chemotherapy in patients with osteogenic sarcoma (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 1175-1185 
    Details
    ISSN: 1619-7089
    Keywords: Dynamic bone scintigraphy ; Factor analysis ; Osteogenic sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prognosis of localized osteogenic sarcoma (OS) has improved considerably since the introduction of neoadjuvant chemotherapy. However, there is a subset of patients who do not show full benefit from neoadjuvant chemotherapy because of chemoresistance. The early identification of poor responders to chemotherapy during neoadjuvant therapy remains difficult. In order to evaluate the role of bone scintigraphy we report our experience of dynamic technetium-99m hydroxymethylene diphosphonate bone scintigraphy in 19 cases of paediatric osteogenic sarcomas. Before the beginning of chemotherapy, a dynamic scan was recorded during 30 min followed by static images at 3 h. The procedure was repeated halfway through the course of chemotherapy (6th week). Histological grading of the response to chemotherapy was carried out in the 12th week, showing nine good responses and ten poor responses. Factor analysis of dynamic structures (FADS) applied to dynamic scans allowed us to identify three factors termed vascular, “soft tissue” and osseous factors. The effect of chemotherapy on each factor was evaluated. Using FADS we were able to detect all the poor histological responders with the combination of vascular and osseous factors. Six out of nine good histological responders were also classified as scintigraphic responders. FADS applied to dynamic bone scans allowed us to identify at an early stage all the poor histological responders to neoadjuvant chemotherapy. This method may have clinical relevance for the therapeutic strategy in patients with OS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171016
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Comparison between factor analysis of dynamic structures and Fourier analysis in detection of segmental wall motion abnormalities: a clinical evaluation (1995)
    Springer
    The international journal of cardiovascular imaging 11 (1995), S. 263-272 
    Details
    ISSN: 1573-0743
    Keywords: radionuclide ventriculography ; Factor Analysis ; Fourier Analysis ; clinical evaluation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate Factor Analysis of Dynamic Structures (FADS) versus or in association with other methods, a protocol was set up including as ‘gold standard’ investigation the left ventricular angiography (LVA) and processing by Fourier Analysis (FA), and FADS with different variants. To refine the diagnosis of Regional Wall Motion Abnormalities (RWMA), processing was done on a sectorial basis for more accurate spatial localization and functional description. 53 patients were studied (8 normal, 45 with coronary artery disease). FADS gave better results than FA on a sectorial basis. Total agreement between FADS and LVA was obtained in 208/265 (78%), while FA was in agreement with LVA in only 167/265 segments (63%). Globally, FADS was significantly better than FA (Z-test: p〈0.05). When only the diagnosis of maximal abnormality was considered, FA and FADS are statistically equivalent. The superiority of FADS vs FA is more obvious in the diagnosis of hypokinesia. Most FA discrepancies corresponded to underestimation of WMA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01145195
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    Paper (German National Licenses)
    Fulltext
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