ISSN:
1432-0738
Keywords:
Key words: Piperonyl butoxide – Hepatocellular carcinoma – Hemangiosarcoma – Carcinogenesis – Mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Male CD-1 mice in groups of 52, 53 or 100 were administered piperonyl butoxide (α-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene) in the diet at levels of 0 (control), 0.6 and 1.2% for 12 months. Hepatocellular carcinoma was induced in treated groups in a dose-dependent manner but not in the control group. The incidences of hepatocellular carcinoma were 11.3 and 52.0% in mice given 0.6 and 1.2% piperonyl butoxide, indicating that piperonyl butoxide can cause hepatocellular carcinoma in mice as it is known to do in rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002040050098
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