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  • 1
    Electronic Resource
    Electronic Resource
    Tegaserod, a 5-HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the efficacy and safety of tegaserod, a novel 5-HT4 receptor partial agonist, in a randomized, double-blind, placebo-controlled, 12-week treatment, multicentre study.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Eight hundred and eighty-one patients with irritable bowel syndrome, characterized by abdominal pain, bloating and constipation, received tegaserod, 2 mg b.d. or 6 mg b.d., or placebo for 12 weeks.〈section xml:id="abs1-3"〉〈title type="main"〉Results:Tegaserod, 2 mg b.d. and 6 mg b.d., showed a statistically significant relief of overall irritable bowel syndrome symptoms, measured by a weekly, self-administered questionnaire. At end-point, treatment differences from placebo were 12.7% and 11.8% for 2 mg b.d. and 6 mg b.d., respectively. The effect of tegaserod was noted as early as week 1, and was sustained over the 12-week treatment period. Individual irritable bowel syndrome symptoms assessed daily also showed a statistically significant improvement of abdominal discomfort/pain, number of bowel movements and stool consistency, and a favourable trend for reducing days with significant bloating. Adverse events were similar in all groups, with transient diarrhoea being the only adverse event seen more frequently with tegaserod than placebo.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:Based upon the results of this study, tegaserod offers rapid and sustained relief of the abdominal pain and constipation associated with irritable bowel syndrome. Tegaserod is also well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.01094.x
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  • 2
    Electronic Resource
    Electronic Resource
    Failure of a motilin receptor agonist (ABT-229) to relieve the symptoms of functional dyspepsia in patients with and without delayed gastric emptying: a randomized double-blind placebo-controlled trial (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Motilin-receptor agonists are prokinetics; whether they relieve the symptoms of functional dyspepsia is unknown. We aimed to test the efficacy of the motilin agonist ABT-229 in functional dyspepsia patients with and without delayed gastric emptying.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Patients were randomized with postprandial symptoms and documented functional dyspepsia by endoscopy (n=589 in intention-to-treat analysis). Patients were assigned to either the delayed or normal gastric emptying strata, based on a validated 13C octanoic acid breath test. Patients were then further randomized within each strata, to receive one of four doses of ABT-229 (1.25, 2.5, 5 or 10 mg b.d. before breakfast and dinner) or placebo for 4 weeks, following a 2-week baseline. The primary outcome was the assessment of change in symptom severity over the 2 weeks from baseline to final visit, based on a self-report questionnaire measuring severity on visual analogue scales.〈section xml:id="abs1-3"〉〈title type="main"〉Results:Baseline characteristics across the treatment arms were very similar. No significant differences in the upper abdominal discomfort severity score (maximum 800 mm) were observed for any active treatment arm vs. placebo (mean change from baseline −139, −141, −145, −160 and −134 mm for placebo, 1.25, 2.5, 5, and 10 mg, respectively, at 4 weeks by intention-to-treat). More patients on placebo reported a good or excellent global response than patients on 1.25 or 5 mg of active therapy (both P 〈 0.05). The results were very similar in those with and without delayed gastric emptying. Helicobacter pylori status did not predict response. Excluding patients with any baseline heartburn (total remaining n=240), ABT-229 10 mg was inferior to placebo in relief of upper abdominal discomfort.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:ABT-229 was of no value for relief of symptoms in functional dyspepsia, compared with placebo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00868.x
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  • 3
    Electronic Resource
    Electronic Resource
    Apoptosis and oxidative status in peripheral blood mononuclear cells of diabetic patients (1999)
    Springer
    Apoptosis 4 (1999), S. 263-270 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; B/T blood lymphocytes ; γ-glutamyltransferase ; glutathione ; glutathione S transferase ; membrane permeability ; type I (IDDM) ; type II (NIDDM) diabetes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have compared the concentrations of intracellular glutathione (GSH), glutathione-dependent antioxidative enzymes, the cell death rate and immunophenotype profile of peripheral blood mononuclear cells (PBMC) from healthy donors and from patients with insulin-dependent type I (IDDM) or non insulin-dependent type II (NIDDM) diabetes mellitus. The IDDM and NIDDM patients had above-normal absolute lymphocyte counts, whereas the percentages of CD3, CD4 and CD8 T lymphocytes were significantly reduced. In contrast, the absolute number and percentage of B lymphocytes was higher in diabetic patients than in healthy donors. The low intracellular reduced glutathione (GSH) and the unbalanced profile of key enzymes involved in GSH metabolism, gamma glutamyltransferase (γ-GT) and glutathione-S-transferase (GST), account for the increased oxidative status of PBMC from diabetic patients. The plasma membranes of PBMC from diabetic patients were less permeable to propidium iodide than those of PBMC from healthy donors, indicating that the apoptotic cell death rate was lower in the cells from diabetic patients. These differences are potentially useful markers of pathogenic metabolic changes which occur during clinical diabetes and if they are confirmed could be used to identify the onset of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026408409916
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of cisapride on relapse of esophagitis (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 551-560 
    Details
    ISSN: 1573-2568
    Keywords: cisapride ; reflux esophagitis ; endoscopic relapse ; symptomatic relapse ; prokinetic treatment ; prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of a prokinetic agent, cisapride, on the relapse of reflux esophagitis was investigated in a randomized, double-blind trial conducted in 443 patients whose esophagitis had previously been healed with an acid antisecretory drug. Patients received cisapride, 20 mg at night, cisapride 10 mg twice daily, or placebo for 12 months or until endoscopic relapse was confirmed endoscopically. In 88% of all patients (respectively 133, 132, and 124), endoscopic data were available at discontinuation of treatment. In comparison with placebo, the two cisapride regimens prolonged both the time to endoscopically confirmed relapse (Kaplan-Meier analysis;P=0.001) and the time to symptomatic relapse (P=0.012). The life-table endoscopic relapse rates at 12 months were 51% for placebo, 32% for cisapride 20 mg at night (P=0.005), and 34% for cisapride 10 mg twice daily (P=0.02). Patients with more severe esophagitis before healing relapsed more rapidly during maintenance therapy, regardless of the treatment regimen. Adverse events were infrequent in all three groups. These findings indicate that maintenance treatment with the prokinetic drug cisapride prevents the relapse of esophagitis after it has been healed by acid antisecretory therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316514
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  • 5
    Electronic Resource
    Electronic Resource
    Relationship Between Benthic Fluxes and Macrophyte Cover in a Shallow Brackish Lagoon (1997)
    Springer
    Water, air & soil pollution 99 (1997), S. 533-540 
    Details
    ISSN: 1573-2932
    Keywords: Ruppia cirrhosa ; epiphyte slime ; oxygen ; sulphide ; disturbance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The relationship between macrophyte cover and benthic fluxes of oxygen, nutrients and sulphide has been examined in a shallow fishpond with a nearly homogeneous meadow of Ruppia cirrhosa (Petagna) Grande (Bassin d'Arcachon, western France). In 1993 and 1994, benthic fluxes were measured in early and late summer. These periods were selected to represent the production and decay phases of Ruppia in order to determine the effect on benthic processes. Benthic fluxes of elements were measured by means of multiple dark and light benthic chambers in the presence or absence of community components. In summer 1994, at the end of the incubation period, profiles of acid volatile sulphide (AVS) and chromium reducible sulphur (CRS) were measured also in the 0-5 cm sediment horizon in cores withdrawn from the dark benthic chambers and from the sediment outside the chambers. Oxygen production and consumption were closely related to macrophyte cover, whilst the contributions of plankton and microphytobenthic communities were less significant. In the water column, dissolved inorganic nutrients were almost totally depleted, while dissolved organic nitrogen attained concentrations up to 200 µM. In late summer, Ruppia biomass underwent a significant decay due to the build up of a thick epiphyte layer, mostly around floating leaves. The epiphyte slime was rich in labile organic matter, the decomposition of which led to a significant oxygen uptake as well as to sulphide production. Therefore, we postulate that epiphyte growth can cause disturbance in the aquatic system keeping dissolved sulphide at very high levels. Biogeochemical reactions, such as precipitation of iron sulphide, can exert a control lowering the amplitude of such disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018312127829
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  • 6
    Electronic Resource
    Electronic Resource
    Relationship between benthic fluxes and macrophyte cover in a shallow brackish lagoon (1997)
    Springer
    Water, air & soil pollution 99 (1997), S. 533-540 
    Details
    ISSN: 1573-2932
    Keywords: Ruppia cirrhosa ; epiphyte slimewoxygen ; sulphide ; disturbance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The relationship between macrophyte cover and benthic fluxes of oxygen. nutrients and sulphide has been examined in a shallow fishpond with a nearly homogeneous meadow ofRuppia cirrhosa (Pelagna) Grande (Bassin d'Arcachon. western France). In 1993 and 1994, benthic fluxes were treasured in early and late summer. These periods were selected to represent the production and decay phases ofRuppia in order to determine the effect on benthic processes. Benthic fluxes of elements were measured by means of multiple dark and light benthic chambers in the presence or absence of community components. In summer 1994. at the end of the incubation period, profiles of acid volatile sulphide (AVS) and chromium reducible sulphur (CRS) were measured also in the 0–5 cm sediment horizon in cores withdrawn from the dark benthic chambers and from the sediment outside the chambers. Oxygen production and consumption were closely related to macrophyte cover, whilst the contributions of plankton and microphytobenthic communities were less significant. In the water column, dissolved inorganic nutrients were almost totally depleted, while dissolved organic nitrogen attained concentrations up to 200 μM. In late summer.Ruppia biomass underwent a significant decay due to the build up of a thick epiphyte layer, mostly around floating leaves. The epiphyte slime was rich in labile organic matter, the decomposition of which led to a significant oxygen uptake as well as to sulphide production. Therefore, we postulate that epiphyte growth can cause disturbance in the aquatic system keeping dissolved sulphide at very high levels. Biogeochemical reactions, such as precipitation of iron sulphide, can exert a control lowering the amplitude of such disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02406893
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    Paper (German National Licenses)
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