Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-0428
    Keywords: Keywords MODY ; late-onset Type II diabetes ; transcription factors ; PAX4 ; BETA2/NEUROD1 ; SSCP.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. The identification of mutations in hepatocyte nuclear factors-1α, –4α, –1β and insulin promoter factor-1 in maturity onset diabetes of the young (MODY) has highlighted the role that transcription factors may have in the development of diabetes. This result has focused molecular genetic studies of diabetes on other transcription factors expressed in the pancreatic beta cell. The basic helix-loop-helix transcription factor BETA2/NEUROD1 (gene symbol, NEUROD1) and the paired box homeodomain transcription factor PAX4 (PAX4) have an important role in islet and beta-cell development. We have examined the contribution of these transcription factors to the development of MODY and late-onset Type II (non-insulin-dependent) diabetes mellitus. Methods. Linkage studies have been done in MODY families reported to have no mutations in the five known MODY genes and in affected sibling pairs from families with late-onset Type II diabetes. Mutation screening of the coding regions of both genes was also realised by SSCP followed by sequencing in MODY patients and in probands with late-onset Type II diabetes. Results. There was no evidence of linkage with the markers for NEUROD1 and PAX4 either with MODY or late-onset Type II diabetes. Mutation screening showed single nucleotide polymorphisms, several of which resulted in amino acid substitutions : NEUROD1, Ala45Thr; PAX4, Pro321His and Pro334Ala. These amino acid sequence variants were not associated with Type II diabetes. Conclusion/interpretation. Our results indicate that NEUROD1 and PAX4 are not a common cause of either MODY or late-onset Type II diabetes in the French Caucasian population. [Diabetologia (1999) 42: 480–484]
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 752 (1995), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 752 (1995), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Agroforestry systems 33 (1996), S. 13-27 
    ISSN: 1572-9680
    Keywords: arboreal strata ; coffee shade trees ; ecological diversity ; mammalian community
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Resumen En el área de Barranca Grande, Estado de Veracruz, México, se estudió la relación que tiene la estructura de la vegetación de los cultivos de café con la diversidad de la comunidad de mamíferos medianos. Para ello, se establecieron 4 transectos fijos de 200 m de largo cada uno, en los que se tomaron los datos de los diferentes estratos. Para conocer la fauna demamíferos, se hizo un muestreo con trampas Tomahawk (178 noches/trampas), registro de rastros así como encuestas a la gente que vive en la zona, entre Octubre de 1989 y Febrero de 1991. Se registraron 24 especies de mamíferos medianos que fueron clasificados utilizando dos medidas de diversidad ecológica, locomoción y forrajeo, para conocer la organización en gremios. Si se reduce la complejidad de los cafetales, puede existir una reducción hasta del 45% en el número de gremios ocupados, 43% en la riqueza y en la diversidad ecológica, y 24% en la equitatividad. Se recomienda mantener una alta diversidad en el estrato arbóreo, en este caso especies como el jinicuil (Inga jinicuil), plátanos (Musa sapientum), cítricos (Citrus spp.), pagua o aguacate (Persea schiedeana), mango (Mangifera indica), serían recomendables ya que proporcionan recursos alimenticios y protección a la mayoría de los mamíferos.
    Notes: Abstract The diversity and organization of the mammalian community is related to the vegetation structure of the coffee plantations in the area of Barranca Grande, in the State of Veracruz, Mexico. Four transects (each 200 m in length) were used to study the vegetation structure within the coffee plantation, and 178 night/traps, tracks registration and information from local people, were used in order to become familiar with the mammaliancommunity. The sample period was from October 1989 to February 1991. The 24 mammals of medium-size species present in the area were classified using two measures of ecological diversity, locomotion and foraging in order to understand the guild organization. If the complexity of the plantation is reduced, the number of guilds occupied could suffer a loss of 45% and 43% in ecological richness and diversity, respectively, and 24% in the equitability of the mammalian fauna. We recommend the maintenance of a high diversity in the tree stratum (shade species), in this case, species such as Inga jinicuil, banana (Musa sapientum), Citrus spp., coyo avocado (Persea schiedeana), mango (Mangifera indica); species which could provide food resources and protection for the mammals.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...