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  • 1
    Electronic Resource
    Electronic Resource
    Positive direct antiglobulin test in a pediatric patient following high-dose cisplatin (1988)
    Springer
    Cancer chemotherapy and pharmacology 21 (1988), S. 85-86 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A positive direct antiglobulin test (DAT) and hemolitic anemia are uncommon side effect of cisplatin (CDDP) therapy. A 9-year-old girl treated for extraosseus Ewing's sarcoma with a multiagent regimen, including 200 mg/m2 CDDP preceded by vincristine (VCR) and cyclophosphamide (CY), developed a posititve DAT, followed by hemolitic anemia. When CDDP therapy was discontinued, the DAT became negative and no signs of anemia were observed during the maintenance treatment, which included VCR and actinomycin D.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262747
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  • 2
    Electronic Resource
    Electronic Resource
    CT of invasive pulmonary aspergillosis in children with cancer (1993)
    Springer
    Pediatric radiology 23 (1993), S. 177-180 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In treating cases of malignancy, the use of chemotherapy carries a high risk of lower respiratory tract infections, especially fungal pneumonopathy. This complication is a major cause of mortality and is often difficult to diagnose because of non-specific clinical or radiological changes, but the early recognition of invasive fungal disease is imperative. CT is an important non-invasive method for the detection and evaluation of opportunistic fungal infections. In these patients an improved survival rate can be achieved when early detection by CT leads to the prompt institution of high-dose antifungal therapy. We illustrate the spectrum of CT findings of invasive pulmonary aspergillosis encountered in children with cancer. These patients had previously been treated with highdose chemotherapy with or without bone marrow rescue, and underwent radiological examinations because of clinical evidence of pneumonopathy. Representative cases demonstrate the clinical applications of CT in the evaluation and management of invasive fungal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013825
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Survival after fungemia due toFusarium moniliforme in a child with neuroblastoma (1993)
    Springer
    European journal of clinical microbiology & infectious diseases 12 (1993), S. 308-309 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967269
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  • 4
    Electronic Resource
    Electronic Resource
    Infection withFusarium species in two children with neuroblastoma (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 773-776 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two cases ofFusarium infection in children with neuroblastoma are reported. One of the patients had an overwhelming infection and the diagnosis was based on isolation ofFusarium moniliforme from blood and skin biopsy, and histological findings. The second patient developed chronic polyarthritis andFusarium solani was cultured from synovial fluid samples taken from two different joints four months apart. No histological documentation of infection was obtained. The response to antifungal therapy was unfavourable. Both patients died, but in the second case the relationship between fungal infection and death was not established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02184694
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  • 5
    Electronic Resource
    Electronic Resource
    Prophylaxis of streptococcal bacteraemia with oral penicillin V in children undergoing bone marrow transplantation (1995)
    Springer
    Supportive care in cancer 3 (1995), S. 319-321 
    Details
    ISSN: 1433-7339
    Keywords: Streptococcal bacteraemia ; Prophylaxis ; Penicillin V ; Bone marrow transplantation ; Paediatrics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The work described aimed to evaluate the incidence of streptococcal bacteraemia in children undergoing bone marrow transplantation and receiving prophylaxis with penicillin V. From January 1991 to December 1993 oral penicillin V was administered as prophylaxis for streptococcal bacteraemia to patients undergoing bone marrow transplantation at G. Gaslini Children's Hospital, Genoa, Italy. The data were compared with those from a similar population receiving bone marrow transplantation from September 1984 to July 1990 and not receiving this kind of prophylaxis. Streptococcal bacteraemia was diagnosed in 7/17 (41%) episodes of bacteraemia observed in the period January 1991 to December 1993, while it accounted for 71% of all bacteraemias in the period from September 1984 to July 1990 and was especially frequent from January 1988 to July 1990, comprising 13/15 (87%) of observed bacteremias. The decrease of this complication observed after the beginning of the prophylaxis programme was statistically significant. Oral penicillin V is effective as prophylaxis of streptococcal bacteraemias in children receiving bone marrow transplantation in a centre with a high incidence of this complication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335310
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  • 6
    Electronic Resource
    Electronic Resource
    Herpes simplex virus and oral mucositis in children with cancer (1994)
    Springer
    Supportive care in cancer 2 (1994), S. 266-269 
    Details
    ISSN: 1433-7339
    Keywords: HSV ; Stomatitis ; Cancer ; Pediatrics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between herpes simplex virus (HSV) and oral mucositis was investigated in children undergoing antineoplastic chemotherapy. HSV culture was performed in 20 children with stomatitis developing after antineoplastic chemotherapy. Viral isolates were typed and susceptibility to acyclovir was investigated. The virus was isolated from oral lesions in 10 of 20 children with severe oral mucositis. Viral reactivation was the most likely explanation in most cases, since HSV was isolated in 9 of 13 seropositive patients (and in 1 patient with unknown anti-HSV serology), but in no seronegative patient. HSV type 1 was isolated more frequently than HSV type 2 (8 versus 2). Acyclovir showed standard in vitro activity against all isolates. Our results suggest that oral mucositis in children receiving antineoplastic treatment is probably multifactorial in origin and that HSV can be an important cofactor, especially in children who are seropositive for HSV. In our Centre, acyclovir remains active in vitro against this opportunistic pathogen and could be employed in prophylaxis and therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365734
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    Paper (German National Licenses)
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