ISSN:
1573-8221
Keywords:
extrapyramidal disorders
;
Parkinsonian syndrome
;
sleep pattern
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Rats with the Parkinsonian syndrome induced by systemic injection of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) develop extrapyramidal disorders (oligokinesia, tremor, and rigidity) which depend on the dose and duration of action of MPTP. At 15 and 30 mg/kg MPTP impairs the learning of the conditioned passive avoidance response, shortens both stages of sleep, particularly the paradoxical (REM) stage, and prolongs the period of wakefulness. The mnestic function disturbance is not associated with extrapyramidal disorders, since it develops in their absence. In MPTP-treated rats memory and sleep disorders are interrelated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446577
Permalink