ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
The Chemistry of Amino Oximes, XV1). - Synthesis of 1,2,5,6-Tetrahydropyrimidine 3-Oxide Derivativesβ-Benzylamino oximes 1a - e were prepared by Mannich reaction and converted into anti-amino oximes 2a - c. By reaction with aldehydes, 1,2,5,6-tetrahydropyrimidine 3-oxides 3a - h were prepared. The N-oxides cyclize with dimethyl acetylenedicarboxylate to give 3a,4,6,7-tetrahydro-5H-isoxazolo[2,3-c]pyrimidine derivatives 4a, b, and g.
Notes:
Die β-Benzylaminoketone 1a - e wurden mittels der Mannich-Reaktion synthetisiert und daraus die anti-Amino-oxime 2a - e hergestellt. Die Umsetzung mit Aldehyden führt zu 1,2,5,6-Tetrahydropyrimidin-3-oxiden 3a - h. Durch Cycloaddition mit Acetylendicarbonsäure-dimethylester entstehen 3a,4,6,7-Tetrahydro-5H-isoxazolo[2,3-c]pyrimidin-Derivate 4a, b und g.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198219821212
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