ISSN:
1573-8353
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract A study has been made of enantioselective hydrosilylation and reduction, by hydrogen transfer, of prochiral alkyl phenyl ketones or alkyl hetaryl ketones over various optically active catalysts. A total of 14 aromatic and heterocyclic carbinols were synthesized with preparative yields of 54–100%. The most effective catalytic systems were found to be complexes of RhCl3 and [Rh(cod)Cl]2 with the known optical inductor (S,S)-i-Pr-Pybox, with which we have obtained for the first time a series of heterocyclic secondary alcohols with an enantioselectivity of 20–63%.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01169246
Permalink