ISSN:
0006-3592
Keywords:
combinatorial chemistry
;
solution-phase
;
high throughput synthesis
;
automation
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Solution-phase high throughput synthesis has emerged as a powerful method for the rapid generation of chemical libraries. The success of this approach is largely due to the development of novel synthetic methodologies that expedite the preparation of compounds. Several isolation/purification techniques have also been developed to eliminate the time-consuming purification procedures often associated with solution-phase chemistry. These methods are amenable to parallel synthesis and combinatorial strategies and can be fully automated. In addition, the compound libraries generated using solution-phase high throughput synthesis have been used to accelerate both lead identification and lead optimization programs at various companies. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 61:95-106, 1998.
Additional Material:
19 Ill.
Type of Medium:
Electronic Resource
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