ISSN:
1573-4927
Keywords:
Culex pipiens
;
esterases
;
organophosphate resistance
;
linkage group
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The highly active esterases A′ and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent K m values (2.1×10−6 m/min/mosquito) but different turnover rates (V m =2.13 and 0.57×10−6 m/min/mosquito, respectively) and pH for maximum activity. Both enzymes have broad substrate specificities and at least one, esterase A′, can hydrolyze OP insecticides. In addition, esterases A′ and B are coded by two closely linked genes, Est-3 and Est-2, respectively (0.67 unit of crossing over), located on the same autosome as pl, a locus attributed to linkage group III. The estimated distance between Est-2 and pl was 9.4 units.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00504256
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