Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Biomedical Engineering
2 (2000), S. 339-376
ISSN:
1523-9829
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Technology
,
Medicine
Notes:
Abstract Antibodies are unique in their high affinity and specificity for a binding partner, a quality that has made them one of the most useful molecules for biotechnology and biomedical applications. The field of antibody engineering has changed rapidly in the past 10 years, fueled by novel technologies for the in vitro isolation of antibodies from combinatorial libraries and their functional expression in bacteria. This review presents an overview of the methods available for the de novo generation of human antibodies, for engineering antibodies with increased antigen affinity, and for the production of antibody fragments. Select applications of recombinant antibodies are also presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.bioeng.2.1.339
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