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Ability of Leucocytes to recognize some Foreign Gamma Globulins during Pinocytosis (1968)

BONA, C. ; GHYKA, GR.

[s.l.] : Nature Publishing Group

Nature 217 (1968), S. 172-173

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Pinocytosis of Igs was investigated by fluorescence microscopy of a mixture of 106 guinea-pig peritoneal exudate cells and 6-6 mg of Igs/ml., incubated for 30 min at 37 0. The guinea-pig peritoneal exudate was obtained after two intraperitoneal injections of polyvinylpyrroli -done and contained ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/217172a0

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Anti-phospholipase C antibodies inhibit the lectin-induced proliferation of human lymphocytes (1987)

Moraru, I. I. ; Manciulea, Mioara ; Călugăru, Anca ; [et al.]

Springer

Bioscience reports 7 (1987), S. 731-736

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ISSN: 1573-4935

Keywords: phosphoinositide hydrolysis ; phospholipase C ; cell proliferation ; lectins ; lymphocytes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%) of PHA (10 μg/ml) or ConA (25 μg/ml) proliferative effects. Thus, the activation of membrane-bound PLC is asine-qua-non condition for lectin-induced proliferation of T lymphocytes. The key-role of PLC versus protein kinase C (PKC) is stressed by the fact that the inhibition of PKC with Hidaka's compound H-7 (40 μM) produced only a partial blockade (about 25%) of lectin mitogenic effect.