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  • 1
    Electronic Resource
    Electronic Resource
    Myosin-1c, the Hair Cell's Adaptation Motor (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 66 (2004), S. 521-545 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Given their prominent actin-rich subcellular specializations, it is no surprise that mechanosensitive hair cells of the inner ear exploit myosin molecules-the only known actin-dependent molecular motors-to carry out exotic but essential tasks. Recent experiments have confirmed that an unconventional myosin isozyme, myosin-1c, is a component of the hair cell's adaptation-motor complex. This complex carries out slow adaptation, provides tension to sensitize transduction channels, and may participate in assembly of the transduction apparatus. This review focuses on the detailed operation of the adaptation motor and the functional consequences of the incorporation of this specific myosin isozyme into the motor complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.66.032102.112842
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Deaf and dizzy mice with mutated myosin motors (1996)
    [s.l.] : Nature Publishing Group
    Nature medicine 2 (1996), S. 27-29 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Genetic hearing deficiencies are common, affecting perhaps as many as 1 in 1,000 children. An even larger fraction of the population, estimated at 10 to 15 percent, experiences significant hearing impairment from illness, trauma, or aging. Advances in the study of hair-cell regeneration have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0196-27
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular basis of mechanosensory transduction (2001)
    [s.l.] : Nature Publishing Group
    Nature 413 (2001), S. 194-202 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mechanotransduction — a cell's conversion of a mechanical stimulus into an electrical signal — reveals vital features of an organism's environment. From hair cells and skin mechanoreceptors in vertebrates, to bristle receptors in flies and touch receptors in worms, mechanically ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35093011
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cadherin 23 is a component of the tip link in hair-cell stereocilia (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 428 (2004), S. 950-955 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mechanoelectrical transduction, the conversion of mechanical force into electrochemical signals, underlies a range of sensory phenomena, including touch, hearing and balance. Hair cells of the vertebrate inner ear are specialized mechanosensors that transduce mechanical forces arising from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature02483
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ion channels Hearing aid (2003)
    [s.l.] : Nature Publishing Group
    Nature 424 (2003), S. 28-29 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sensory information, such as that carried by light, odours and sound, continuously washes over us, revealing the nature of the outside world. Because organisms place a premium on detecting such signals with high specificity and sensitivity, specialized cells have evolved to capture each type of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/424028a
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    Paper (German National Licenses)
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