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  • 1
    Electronic Resource
    Electronic Resource
    Orbital varices: a tricky diagnosis in MRI (1995)
    Springer
    European radiology 5 (1995), S. 33-35 
    Details
    ISSN: 1432-1084
    Keywords: Intermittent exophthalmos ; Orbital varix ; CR ; MR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Orbital varix (OV) is a rare condition causing intermittent positional exophthalmos. Because of low venous pressure, OVs tend to collapse, being frequently undetectable in routine CT or MRI examinations. We describe one case of giant intraorbital varix studied with CT and MRI techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178078
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  • 2
    Electronic Resource
    Electronic Resource
    Blood-ocular barrier damage: use of contrast-enhanced MRI (1997)
    Springer
    European radiology 7 (1997), S. 110-114 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Blood-ocular barrier ; Blood-brain barrier ; MRI ; Gd-DTPA ; Eye
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The blood-ocular barrier (BOB) shares similar neuroepithelial origin, microanatomy and functions with the blood-brain barrier. There are many natural (e. g. diabetes, hypertension) or iatrogenic (chemotherapy, retinal photocoagulation) conditions which can cause a BOB breakdown, resulting in visual acuity impairment or loss. The authors examined 42 patients affected by BOB damage in different pathological conditions. All patients previously underwent a conventional fluoroangiographic (FA) study. Nine patients with normal FA exam were evaluated also. Despite normal MRI findings immediately after Gd-DTPA injection, contrast leakage into the vitreous body or into the aqueous fluid was demonstrated in delayed scans (40–50 min after contrast administration), proving the existence of a BOB damage (sensitively 94 %). Although FA exam remains the choice modality in BOB breakdown demonstration, we propose MRI as a useful diagnostic tool when optic media opacity (cataract, haemovitreous, intraocular silicon oil) occurs, preventing direct retinal fundus imaging and/or an early screening tool.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050121
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical expression of metallothionein in normal human colorectal mucosa, in adenomas and in adenocarcinomas and their associated metastases (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 29 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The immunohistochemial distribution pattern of metallothionein, a low molecular weight protein with strong affinity for divalent heavy metal ions, has been investigated in normal and neoplastic conditions of the large bowel. Utilizing a monoclonal mouse antibody the following formalin-fixed paraffin-embedded surgical or biopsy samples were studied: tubulo-villous adenomas (8 cases); adenocarcinomas with various degree of differentiation (85), nine of which were mucinous-type; synchronous tubular or tubulo-villous adenomas separate from carcinomas (30); transitional mucosa (45); metastases in lymph nodes (43); and distant metastases (45). Twenty biopsies from the right and left colon of 10 patients affected by irritable bowel syndrome were also analyzed. Normal colonic mucosa as well as transitional mucosa showed metallothionein immunopositivity in enterocytes at the luminal surface and crypts. Evident nuclear and cytoplasmic staining was encountered in tubulo-villous adenomas; the same reactivity was noted in the basal glandular component of colorectal carcinomas-synchronous adenomas, while less intense staining was noted in the apical villous portions. A variable metallothionein immunostaining was observed in adenocarcinomas (62.3%), in lymph node (55.8%) and distant hepatic (17.2%) and omental (43.8%) metastases, although it was not always concordant with that reported in the corresponding primary tumour. Whether the metallothionein positivity observed in normal and neoplastic cells is the result of expression of a stable form of the protein or an accumulation in the nucleus and cytoplasm remains to be clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1996.tb01418.x
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  • 4
    Electronic Resource
    Electronic Resource
    The value and significance of nucleolar organizer region (AgNOR) proteins in ulcerative colitis and adenocarcinomas of the large bowel (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 22 (1993), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1993.tb00181.x
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  • 5
    Electronic Resource
    Electronic Resource
    Detection of Tn, sialosyl-Tn and T antigens in hereditary nonpolyposis colorectal cancer (1996)
    Springer
    Virchows Archiv 429 (1996), S. 344-352 
    Details
    ISSN: 1432-2307
    Keywords: Colorectal cancer ; Hereditary nonpolyposis colorectal cancer ; Carbohydrate antigens ; Lectin histochemistry ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the ‘cryptic’ sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway. Utilizing monoclonal antibodies anti-Tn antigen (HB-Tn1), anti-sialosyl-Tn antigen (HB-STn1), anti-T antigen (HB-T1) and the biotinylated Amaranthus caudatus agglutinin (ACA), we have investigated the expression of the simple mucin-type carbohydrate antigens in hereditary nonpolyposis colorectal cancer (HNPCC; 15 cases) compared with sporadic colorectal cancer (CRC; 60 cases) and normal colonic mucosa (30 cases). A variable positivity of Tn, sialosyl-Tn, T and the cryptic sialylated form of this latter antigen was encountered in both HNPCC and sporadic CRC cases; in addition, in normal colonic mucosa a constant reactivity was encountered only for Tn and the cryptic sialylated form of T, while negative results were always obtained for sialosyl-Tn and T antigens. Statistical analysis, performed using a Chi-square test, showed significantly lower (P=0.037) expression of sialosyl-Tn and higher (P=0.022) expression of T in HNPCC than in sporadic CRC, suggesting a greater presence of β1,3 galactosyl-transferase activity in HNPCC than in sporadic CRC. We were unable to identify a peculiar phenotype for HNPCC with simultaneous evaluation of reactivity for HB-Tn1, HB-STn1, HB-T1 and ACA; the biological significance of the preferential expression of T antigen in HNPCC remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198438
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  • 6
    Electronic Resource
    Electronic Resource
    Immunohistochemical expression of metallothioneins in colorectal adenocarcinoma (1996)
    Springer
    Virchows Archiv 427 (1996), S. 547-548 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199517
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  • 7
    Electronic Resource
    Electronic Resource
    Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: Correlation with clinico-pathological features (1993)
    Springer
    Virchows Archiv 423 (1993), S. 51-55 
    Details
    ISSN: 1432-2307
    Keywords: DNA topoisomerase type II ; Cell proliferation ; Breast carcinoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract DNA topoisomerase type II (DT-II) is a major component of interphase nuclear matrix fractions, present in S-phase of the cell cycle. A series of 80 carcinomatous breast surgical samples was evaluated by immunohistochemistry, using a polyclonal antibody in a comparison with Ki-67 antiserum. A correlation with clinico-pathological data was also performed. Infiltrating ductal and lobular carcinomas constantly express DT-II with varying intensity of nuclear staining; a similar immunohistochemical pattern is observed with Ki-67. A frequent co-expression of DT-II and Ki-67 is encountered with double immunostaining; accordingly to these data, a linear relationship is evident when linear regression is employed. In addition, significant relationships between DT-II values and tumour size, histological grade and node involvement are shown, while an inverse correlation is appreciable between DT-II and oestrogen receptors and progesterone receptors. DT-II may be considered to be an additional operational marker for the proliferating fraction of cells in breast carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606432
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  • 8
    Electronic Resource
    Electronic Resource
    Idiopathic intracranial hypertension: orbital MRI (1995)
    Springer
    Neuroradiology 37 (1995), S. 459-461 
    Details
    ISSN: 1432-1920
    Keywords: Key words Idiopathic intracranial hypertension ; Visual loss ; Magnetic resonance imaging ; Blood-retinal barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case is reported of a patient with idiopathic intracranial hypertension examined with magnetic resonance imaging. Marked enhancement of the optic nerve heads was found, which might be related to blood-retinal barrier breakdown related to a sudden rise in intracranial cerebrospinal fluid pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600093
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  • 9
    Electronic Resource
    Electronic Resource
    Choroidal filling pattern during a hypotensive crisis (1987)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 225 (1987), S. 154-155 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02160350
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  • 10
    Electronic Resource
    Electronic Resource
    Electrofunctional features of the tilted disc syndrome (1986)
    Springer
    Documenta ophthalmologica 62 (1986), S. 223-230 
    Details
    ISSN: 1573-2622
    Keywords: tilted disc syndrome ; electroretinogram ; electrooculogram ; visual evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ERG, EOG and VEPs of 15 patients with tilted disc syndrome were studied. The ERG showed abnormal amplitudes in about 1/4 of the eyes and the EOG values were pathological in 3 patients. It is probable that the abnormality of the inferiornasal portion of the retina and retinal pigment epithelium seen in the tilted disc syndrome causes the changes in the ERG and EOG. Pattern VEPs latency was delayed in most patients. This finding is probably due to the poor focusing of the light in the retina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212648
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