ISSN:
1573-4986
Keywords:
α1,3fucose
;
α1,6fucose
;
sialic acid
;
polyα2,8sialic acid
;
surface membrane glycoforms
;
cystic fibrosis
;
lactosylated polylysine gene therapy vector
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Terminal glycosylation has been a recurring theme of the laboratory. In cystic fibrosis (CF), decreased sialic acid and increased fucosyl residues in α1,3 position to antennary N -acetyl glucosamine is the CF glycosylation phenotype. The glycosylation phenotype is reversed by transfection of CF airway cells with wtCFTR. In neuronal cells, polymers of α2,8sialyl residues are prominent in oligodendrocytes and human neuroblastoma. These findings are discussed in relationship to early studies in our laboratories and those of other investigators. The potential extension of these concepts to future clinical therapeutics is presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1011034912226
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