ISSN:
1573-9031
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The metabolism of the antiviral drug arbidol was studied on rats with peroral administration. Mass spectrometry, thin-layer and high-performance liquid chromatography showed that the biotransformation of arbidol occurs with the loss of a dimethylaminomethyl substitutent in position 4, and sulfoxidation occurs with the formation of the corresponding sulfones and sulfoxides. The drug undergoes conjugation at the hydroxyl group with the formation of the glucuronide and sulfate, and also the glucuronide and sulfate of the product of demethylation of arbidol at the dimethylamino group.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02226513
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