ISSN:
1432-0428
Keywords:
Key words IDDM, MHC, tumour necrosis factor alpha, polymorphism.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Insulin-dependent diabetes mellitus (IDDM) is associated with class II molecules of the MHC on chromosome 6, in particular HLA-DR and -DQ alleles, but a pathogenic role for TNF-α in the class III region of the MHC has also been implied. We therefore tested whether there was any independent association between a biallelic TNF polymorphism and IDDM. The TNF2 allele was present in 61 of 114 (54 %) IDDM patients compared to 101 of 253 (40 %) control subjects (odds ratio 1.73; p〈0.02). Stratification analysis in individuals matched for HLA-DR3 revealed, however, that this association was not independent of HLA-DR3 and is most likely to be a result of linkage disequilibrium between these alleles. [Diabetologia (1994) 37: 500–503]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001250050138
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