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  • 1
    Electronic Resource
    Electronic Resource
    Ecdysone and DNA Puffs (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 605-605 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-In the December 14 issue of Nature (220, 1078; 1968) your cell biology correspondent referred to a paper by Grouse (Proc. US Nat. Acad. Sci., 61, 971; 1968) in which some experiments of ours were repeated concerning the prevention of puff formation in Sciara coprophila by cortisone. In our ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/222605a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Conservation of nonhistone chromosomal proteins through dipteran evolution (1980)
    Springer
    Chromosoma 79 (1980), S. 65-74 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have investigated the possibility that some high molecular weight nonhistone chromosomal (NHC) proteins may have been conserved through the evolution of two distantly related diptera-Drosophila melanogaster and Sciara coprophila. Antisera produced against three NHC protein subfractions were analyzed for cross-reactivity with Sciara polytene chromosomes. The indirect immunofluorescent staining technique used couples an assay for immunologic cross-reactivity with an assay for the in situ distribution of the proteins under study. The results indicate that the σ-φ and ϱ NHC protein antigens have been conserved since the divergence of Drosophila and Sciara, while the Drosophila π NHC protein antigen is not present on Sciara chromosomes. In one case, with anti-σ-φ serum, we have identified a highly conserved, very high molecular weight NHC protein (or class of proteins) which appears to interact strongly with all chromatin in a manner which is not DNA sequence-specific. In the second case, with anti-ϱ serum, we have identified an NHC protein which may have evolved an additional function(s) in Sciara relative to its function(s) in Drosophila.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00328473
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in levels of c-myc and histone H2B following exposure of cells to low-frequency sinusoidal electromagnetic fields: Evidence for a window effect (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 11 (1990), S. 269-272 
    Details
    ISSN: 0197-8462
    Keywords: c-myc ; histone H2B ; dot-blot hybridization ; transcription ; human cells ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Human HL-60 cells were exposed for 20 min to an electromagnetic field at frequencies ranging from 15 to 150 Hz and at densities from 0.2 to 2.3 mT (2 to 23 gauss). Following each exposure, quantitative levels of c-myc and histone H2B transcripts were determined by dot-blot hybridization analyses and compared with unexposed control samples. The most pronounced increase in each transcript occurred after exposure at 45 Hz, with levels more than four times that found in unexposed controls.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250110403
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  • 4
    Electronic Resource
    Electronic Resource
    Amplitude windows and transiently augmented transcription from exposure to electromagnetic fields (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 11 (1990), S. 297-312 
    Details
    ISSN: 0197-8462
    Keywords: ELF fields ; transient response ; chemical-reaction model ; rate constant ; RNA synthesis ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The exposure of cells to relatively low-intensity, pulsed, low-frequency electromagnetic fields can result in a transient augmentation of mRNA synthesis. Under certain conditions of irradiation, the augmentation is a function of the strength of the electromagnetic field. A linear, multi-step, chemical-reaction model accounts for many of the principal features that are observed in both the time- and intensity-dependent variations of transcriptional effects. The crucial assumption in the model is that the direct effect of electromagnetic fields on exposed cells is an increase in the rate constant that characterizes one of the intermediate sequential reactions in the synthesis of mRNA.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250110406
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  • 5
    Electronic Resource
    Electronic Resource
    Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 15 (1994), S. 329-336 
    Details
    ISSN: 0197-8462
    Keywords: transcription ; translation ; SV-40 ; large T-antigen ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: In its integrated form, SV-40 DNA offers an opportunity to observe the behavior of what is in effect a viral genome within a cellular genome, with transcriptional and translational products that can be clearly distinguished from those of the host cell. Exposure of SV40-transformed human fibroblasts to a 60 Hz continuous-wave sinusoidal electromagnetic (EM) field resulted in increased levels of virally derived mRNA and protein of large T-antigen. These findings provide evidence that a foreign DNA integrated into cells can be affected by EM fields under conditions known to cause increased transcripts from endogenous cellular genes. © 1994 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250150407
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  • 6
    Electronic Resource
    Electronic Resource
    Transcriptional patterns in the X chromosome of Sciara coprophila following exposure to magnetic fields (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 8 (1987), S. 1-7 
    Details
    ISSN: 0197-8462
    Keywords: magnetic fields ; transcriptional increases ; polytene chromosomes ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: We previously demonstrated that exposure of salivary gland cells of the dipteran, Sciara coprophila, to either asymmetrical or symmetrical changing magnetic fields results in an increase in the incorporation of radioactive uridine into RNA. The present report is an analysis of the grain count distribution over the X chromosome of Sciara in transcription autoradiograms following exposure of the salivary gland cells to two pulsed magnetic signals and a 72-Hz sine wave signal. The results show augmented uptake of 3H-uridine into nascent RNA chains following short exposures of the cells to magnetic fields. Transcription is augmented in previously active loci, as well as at chromosome regions that are not detectable as active in control cells. The quantitative pattern of RNA synthesis in transcription autoradiograms is hypothesized to be signal specific on the basis of differences in grain counts over significantly labelled chromosome sites.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250080102
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  • 7
    Electronic Resource
    Electronic Resource
    Reply to R. K. Adair (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 19 (1998), S. 138-138 
    Details
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: No abstract.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 8
    Electronic Resource
    Electronic Resource
    Transcription in Drosophila melanogaster salivary gland cells is altered following exposure to low-frequency electromagnetic fields: Analysis of chromosome 3R (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 13 (1992), S. 111-118 
    Details
    ISSN: 0197-8462
    Keywords: ELF EM fields ; transcription autoradiography ; Drosophila chromosomes ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The use of the transcription autoradiographic method permits identification of nascent RNA chains directly on identifiable regions of Drosophila salivary gland chromosomes. Changes in transcriptional activity at 13 defined regions of the right arm of chromosome 3 (3R) were observed following 20-min exposures of salivary glands to five different extremely low frequency (ELF) electromagnetic (EM) fields. Changes in translational patterns were also induced by the ELF EM fields in exposed cells. Differences included an increase in over-all polypeptide synthesis as well as in the number of polypeptides resolved in cells exposed to EM fields. © 1992 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250130205
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  • 9
    Electronic Resource
    Electronic Resource
    Sine waves enhance cellular transcription (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 7 (1986), S. 23-29 
    Details
    ISSN: 0197-8462
    Keywords: electromagnetic fields ; transcriptional increases ; polytene chromosomes ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: We previously showed that quasirectangular, asymmetrical, pulsed electromagnetic (EM) fields of low frequency can induce increased transcription in Sciara salivary gland cells. A symmetrical sine wave with the same frequency as known biologically effective asymmetric signals was studied in the present investigations. The results demonstrated that signal shape was not a major factor in causing augmented transcription. The pattern of grain density in transcription autoradiograms, as well as the size classes of RNA responsive to EM fields, was the same irrespective of asymmetry or symmetry of the signal. Following short-term exposure of the cells to either type of EM field, S values of new transcripts were consistent with those expected for processed and unprocessed messenger RNA.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250070104
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  • 10
    Electronic Resource
    Electronic Resource
    Do electromagnetic fields interact directly with DNA? (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 18 (1997), S. 111-115 
    Details
    ISSN: 0197-8462
    Keywords: signal transduction ; transcription ; biosynthesis ; Na,K-ATPase ; mobile charges ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The mechanisms whereby electromagnetic (EM) fields stimulate changes in biosynthesis in cells are not known. It has generally been assumed that EM fields first interact with cell membranes, but this pathway may not be the only one. Interactions with membranes are well documented, but recent studies of EM signal transduction in the membrane Na,K-ATPase are best explained by direct interaction of electric and magnetic fields with mobile charges within the enzyme. Interaction with moving charges may be a mechanism that is operative in other biopolymers. Recent studies on DNA have shown that large electron flows are possible within the stacked base pairs of the double helix. Therefore, gene activation by magnetic fields could be due to direct interaction with moving electrons within DNA. Electric fields as well as magnetic fields stimulate transcription, and both fields could interact with DNA directly. The mechanism of EM field-stimulated transcription may be related to the process in striated muscles, where endogenous electrical activity induces the synthesis of new proteins. Bioelectromagnetics 18:111-115, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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