Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 11 (1987), S. 126-132 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'oxymétrie tissulaire déjà employée dans quelques centres est porteuse de promesses considérables sur le plan de la clinique. La méthode possède la capacité de monitorer la distribution de l'oxygène et d'apprécier la perfusion des tissus. Pour les auteurs de l'article, elle est susceptible également de constituer un appoint considérable pour prévenir l'apparition des complications chirurgicales et pour traiter les infections chirurgicales. Les instruments actuels sont d'un emploi relativement difficile, mais leur potentiel n'a pas été assez utilisé en raison de conceptions inexactes concernant le transport de l'oxygène dans les tissus et l'importance de la perfusion périphérique. L'oxymétrie permet de mesurer directement la perfusion périphérique alors que les indices couramment utilisés, tel que le débit urinaire, ne sont que des indications indirectes conduisant souvent à des erreurs. Fort de ces faits, les auteurs de l'article passent en revue les concepts de base de l'oxygénation tissulaire, la valeur de la pression partielle de l'oxygène tissulaire, la connexion avec la perfusion, les différentes techniques de mesure de l'oxygénation tissulaire et les méthodes actuellement disponibles.
    Abstract: Resumen La oximetría tisular, la cual ya es una realidad práctica en algunos centros médicos, aparece como promisoria para el uso clínico. Posee la capacidad de monitoría del sistema de provisión tisular de oxígeno y de estimar la perfusión de los tejidos; se espera que pueda contribuir en forma considerable a la prevención de las complicaciones quirúrgicas y al tratamiento de las infecciones en cirugía. Los instrumentos actuales son de difícil uso, pero su potencial no ha sido utilizado en razón, principalmente, de las concepciones erróneas que existen sobre el transporte del oxígeno en los tejidos y el significado de la perfusión periférica. La oximetría mide la perfusión tisular, mientras algunos índices de uso común, tal como el volumen urinario, son sólo indicadores indirectos y con frecuencia engañosos. En este trabajo se discuten los conceptos básicos de oxigenación, la pertinencia de la presión parcial de oxígeno en los tejidos, la relación con la perfusión, las diversas tecnologías para medir oxigenación tisular, y los métodos actualmente disponibles.
    Notes: Abstract Tissue oximetry, already a practical reality in some centers, holds considerable promise for clinical use. It has the capacity to monitor the oxygen delivery system and estimate perfusion of tissues; and we suspect it can add considerably to prevention of surgical complications and treatment of surgical infections. Present instruments are relatively difficult to use, but their potential is not being utilized largely because of misconceptions about the transport of oxygen in tissue and the significance of peripheral perfusion. Oximetry measures perfusion, whereas currently popular indices such as urine output are indirect indicators and are often misleading. The basic concepts of tissue oxygenation, the relevance of partial pressure of oxygen in tissue, the connection with perfusion, various technologies for measuring tissue oxygenation, and the currently available methods are discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1573-7217
    Keywords: breast cancer ; bromodeoxyuridine ; functional relationship ; human study ; in vivo ; Ki-67 ; prognosis ; proliferation markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Proliferation indices are used, along with other parameters, to estimate the risk of recurrence of breast cancer for individual patients. Because it is unlikely one index will be practical for all patients, it is important to understand the relationship between various indices of proliferation. For this reason, we compared a proliferation index based on in vivo labeling of S-phase tumor cells with the thymidine analog bromodeoxyuridine (BrdUrd), to a proliferation index based on an estimate of the growth fraction with the MIB-1 antibody to the Ki-67 antigen. With informed consent, we gave 145 patients 200 mg/m2 BrdUrd intravenously just prior to surgical removal of breast cancer. On histology sections, we visually counted S-phase cells which had incorporated BrdUrd using the Br-3 antibody which is specific to DNA-incorporated BrdUrd, and we counted cells in the growth fraction using the MIB-1 antibody to the Ki-67 antigen. We found that both indices were positively correlated with tumor size, number of positive nodes, and tumor grade, and both were negatively correlated with age and estrogen-progesterone receptor positivity. Using a linear functional relationship model, we found that the best (i.e. the maximal) fit between the two indices (correlation coefficient 0.79; p 〈 0.0001) occurred when each index was square root transformed, as is appropriate when counts follow a Poisson distribution. When we used the median as a cutpoint for each index, the classification of 19 percent of data pairs changed depending upon which index was used. We also estimated that the Ki-67 intercept (1.02 ± 0.25) was significantly greater than zero. We conclude that the BrdUrd index of DNA synthesis in S-phase correlates highly with the MIB-1 index of the growth fraction, and both indices correlate well with other parameters of tumor aggressiveness. Because this correlation is driven by concordance of the extremes of high and low counts, clinical comparison will be necessary to determine which is the better prognostic marker for human breast cancer.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1573-7217
    Keywords: breast cancer ; bromodeoxyuridine ; Ki-67 ; nodes ; survival ; S-phase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Proliferation indices are intended to help patients and clinicians make treatment decisions. We have previously demonstrated that a proliferation index based on in vivo labeling of S-phase cells with bromodeoxyuridine (BrdUrd) correlates with Ki-67 labeling index (LI). We now compare the prognostic value of these indices. With written consent, we gave 129 women with biopsy confirmed breast cancer 200 mg/M2 BrdUrd during 30 min immediately preceding surgery. We used IU-4 anti BrdUrd antibody to count the immunohistochemical labeling index (LI) of DNA-incorporated BrdUrd in 2,000 cells and MIB-1 to count Ki-67 (118 cases). Patients received standard surgical and adjuvant treatment. No patients were lost to follow-up and patients were followed a minimum of 2 (median 5.1) years. We compared survival and recurrence in tumors with high vs low labeling indices. We found that women in the low BrdUrd LI group had better disease free survival (92% vs 67% 5-yr DFS p = 0.001) and overall survival (94% vs 70% 5-yr OS, p = 0.0001) than those with a high LI. In comparison, a low Ki-67 index predicted better OS (87% vs 80% 5-yr OS, p = 0.020) and a trend for better DFS (84% vs 72% DFS p = 0.055). The apparent superiority of BrdUrd LI over Ki-67 LI is likely due to chance (p = 0.18). In multivariate survival analyses we found that BrdUrd LI proliferative index significantly improves prediction of DFS or OS even when node status, age or tumor size is in the model. We conclude that markers of proliferation are useful adjuncts in predicting patient prognosis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...