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  • 1
    Electronic Resource
    Electronic Resource
    Effects of 5-fluorouracil on cytotoxicity and RNA metabolism in human colonic carcinoma cells (1989)
    Springer
    Cancer chemotherapy and pharmacology 25 (1989), S. 37-44 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cytotoxicity of 5-fluorouracil (5-FU) is due in part to the incorporation of the base into RNA molecules. We assessed the cytotoxicity of 5-FU in human colonic carcinoma HT-29 cells and examined mRNA activity (measured by protein biosynthesis in vivo and in vitro) and the maturation of rRNA precursors as two possible modes of action of 5-FU. The rRNA processing pathways were studied using rDNA sequences as probes in blot hybridisation protocols and were specific for both the precursors and mature rRNA species of the maturation pathways. The conclusion from the studies was that although differences in mRNA activity were detected in vivo and in vitro, the significance of these changes are as yet unknown. In contrast, the effects on the pre-rRNA processing pathways proved to be highly significant cytotoxic consequences of 5-FU administration. We discuss the implications of this finding for an understanding of the mode of action of the drug and for the future monitoring of tumour sensitivity to 5-FU.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694336
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  • 2
    Electronic Resource
    Electronic Resource
    Low frequency coherent anti-Stokes Raman spectroscopy of air (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 378-379 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Schematic representation of a, three-colour CARS; b, four-colour CARS. The technique is briefly as follows: when a sample is irradiated with two lasers at frequencies vv and v2 a signal is generated at a frequency 2v1- v2=v3 (see Fig. 1a). The signal intensity is proportional to I2v1 Iv2 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276378a0
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  • 3
    Electronic Resource
    Electronic Resource
    A study of CARS nitrogen thermometry at high pressure (1990)
    Springer
    Applied physics 51 (1990), S. 31-38 
    Details
    ISSN: 1432-0649
    Keywords: 42.65c ; 78.30
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The accuracy of CARS N2 thermometry has been assessed using carefully measured experimental data at high pressures for the temperature range 295 to 870 K and pressure range 1–20 bar. Excellent agreement between calculated and experimental spectra was achieved using statistically based fitting laws to model rotational relaxation. Temperature errors of within ±60 K were achieved using the MEG fitting law, and within ±30 K using an extension to the model (XMEG). Results of separate ab initio IOS calculations with ECS corrections for rotational relaxation gave good overall agreement but did not model the structure of the motionally narrowed spectra as well as the empirical models. The various models were also compared with some complementary data measured by DLR, Stuttgart in their high pressure burner for pressures up to 40 bar. This study also investigated the sensitivity of CARS thermometry to pressure; in certain regions a significant reduction in sensitivity was found. Other key factors investigated include nonlinearities in the intensified diode array detector.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332321
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  • 4
    Electronic Resource
    Electronic Resource
    Degenerate four-wave mixing in nitrogen dioxide: Application to combustion diagnostics (1992)
    Springer
    Applied physics 54 (1992), S. 271-277 
    Details
    ISSN: 1432-0649
    Keywords: 82.40.Py ; 33.20.Kf ; 07.65.-b
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Single shot degenerate four wave mixing (DFWM) images of the distribution of nitrogen dioxide (NO2) doped into a propane/air flame at concentrations of the order of 7000 ppm have been obtained. These images indicate the relative concentration of NO2 in different parts of the flame with an estimated spatial resolution of 150 μm. Initial experiments were performed using NO2 in a glass cell with nitrogen buffer gas. DFWM signals were generated using both the frequency doubled output of a pulsed ND:YAG laser and the tunable blue output of an excimer pumped dye laser. The signal was investigated as a function of laser power, NO2 concentration and buffer gas pressure. In addition, spectra of NO2 in the region 450 to 480 nm were obtained. Signals were then sought in both a cold air/NO2 gas flow and an ignited mixture of propane and air seeded with NO2, using a DFWM imaging geometry. The resulting images from the flame demonstrate the disappearance of the NO2 molecules in the flame interaction zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00325192
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  • 5
    Electronic Resource
    Electronic Resource
    CARS vibration-rotation Q-branch spectrum of hydrogen chloride (1991)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 22 (1991), S. 467-471 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The self-broadening of the Q-branch vibration-rotational lines in the CARS spectrum of HCl was studied over the pressure range 0.002-1.000 bar and the temperature range 298-1048 K. The broadening coefficients, σp, are dependent on J at 298 and 550 K but are independent of J at higher temperatures; the σp value of 1048 K is only about 25% of its value for Jmax at 298 K.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250220808
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  • 6
    Electronic Resource
    Electronic Resource
    Temperature and pressure dependence of the ν1 band of water vapour by high-resolution inverse Raman spectroscopyThis work was supported by the AEA Technology Underlying Programme and the US Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences. (1990)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 21 (1990), S. 847-855 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman spectrum of the ν1 band of water vapour at pressures up to 300 τ and for five temperatures between 300 and 1200 K was measured using high-resolution inverse Raman spectroscopy. Self-broadening coefficients were determined for 59 distinct lines from J = 0 to J = 11. The temperature dependence of these coefficients was also determined for most of these lines and was compared with previously published calculations. Spectral regions where deviations have been previously observed between measured and calculated CARS spectra of the ν1 band were studied in detail. Corrections to line positions and relative intensities are suggested for improving the current water vapour spectral model.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250211214
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  • 7
    Electronic Resource
    Electronic Resource
    Redetermination of some of the spectroscopic constants of the electronic ground state of di-Nitrogen 14N2, 14N15N and 15N2 using coherent anti-stokes Raman spectroscopy (1980)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 9 (1980), S. 361-368 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Calibrated coherent anti-Stokes Raman (CARS) spectra have been recorded for the resolved Q branches of the vibrational fundamentals and first hot bands of 14N2, 14N15N and 15N2 at a temperature of 1200 K. The spectra show a convolved linewidth of 0.13 cm-1, and have been used to derive new values of spectroscopic constants, for the species observed, with specific reference to the position of the Q branch lines where J 〉 20 for v = 1-0, and J = 0-30 for v = 2-1. The critical overlap region of the fundamental and the hot band may now be computer simulated with confidence, which should be of considerable help in combustor thermometry using CARS.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250090604
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  • 8
    Electronic Resource
    Electronic Resource
    Chromium oxide film thickness measurements using spontaneous Raman scattering (1984)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 15 (1984), S. 156-159 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Quantitative measurements of chromium oxide film thicknesses on pure chromium have been made using Raman scattering. The results are compared with those from argon ion erosion. Possible developments of the technique to the chemical mapping of corrosion film using Raman scuttering are discussed.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250150305
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