ISSN:
1432-1076
Keywords:
Sodium benzoate
;
Hyperammonaemia
;
Carbamyl derivatives
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Sodium benzoate has been recommended for the treatment of hyperammonaemia in humans. However, benzoate potentiates ammonia toxicity and reduces urea synthesis in vitro and in vivo by decreasing the intramitochondrial levels of N-acetyl glutamate. Pretreatment of mice with carbamyl glutamate, a structural analogue of N-acetyl glutamate, decreases mortality induced by ammonium acetate and sodium benzoate administration. The protective effect of carbamyl glutamate is accompanied by an increase in urea production and of carbamyl phosphate synthetase activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441553
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