ISSN:
1600-0536
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been used extensively in various products since the 1980s. Recently, a biocide containing only MI and not MCI has been launched on the Swedish market for use in industrial settings, paints and glues.Objectives: To describe sensitization to the unchlorinated isothiazolinone 2-methyl-4-isothiazolin-3-one (MI) in 2 workers, a technician after a chemical burn and a painter, both exposed to a preservative containing MI. Methods: Patch testing with serial dilutions of MCI/MI, MCI, MI, 2-n-octyl-4-isothiazolin-3-one (OIT) and a commercial preservative containing MI in the 2 workers.Results: The patients reacted positively to MCI/MI and to the separate active ingredients (MCI, MI). The patch test reactivity to MI was higher than the reactivity to MCI, which is a reversed pattern to what is usually seen in patients sensitized to MCI/MI. Both patients also had positive test reactions to OIT.Conclusion: MI may sensitize on it’s own, and in patients allergic to MI, cross-reactions are also seen to MCI.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.0105-1873.2004.0309ar.x
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