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  • 1
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    JOHN RUSKIN AND THE VICTORIAN EYE (1993)
    Kingston, R.I., etc. : Periodicals Archive Online (PAO)
    The Historian. 55:2 (1993:Winter) 253 
    Details
    ISSN: 0018-2370
    Topics: History
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3109-1993-055-02-000002
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of arginine on the coexistence ofStreptococcus mutans andS. milleri in glucose-limited mixed continuous culture (1987)
    Springer
    Microbial ecology 14 (1987), S. 193-202 
    Details
    ISSN: 1432-184X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Dental plaque is a complex community of bacteria coexisting in an environment frequently limited by carbon and energy sources. UnlikeStreptococcus mutans, other oral streptococci such asS. milleri andS. sanguis have an absolute requirement for and actually consume all available arginine when grown glucose limited in a chemically defined medium. The conditions, particularly in terms of arginine concentration, under which the dental plaque bacteriaS. mutans andS. milleri would coexist under glucose-limiting conditions were investigated. The minimum level of arginine supporting optimal growth ofS. milleri was found to be ca. 50μM, and above this level these strains outcompetedS. mutans. However, coexistence withS. mutans could be achieved at arginine levels of 14–40μM, depending upon theS. milleri andS. mutans strains used. Under such dual limitation,S. milleri was unable to respond to glucose pulses but did respond to pulses of arginine and arginine plus glucose. One of the twoS. milleri strains did not tolerate low pH. In contrast,S. mutans did not tolerate high pH whereasS. milleri was unaffected. This is relevant to dental plaque where arginine catabolism produces a pH rise. Additionally, arginine is an important nutrient since it can be used as an energy source by some oral streptococci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012940
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  • 3
    Electronic Resource
    Electronic Resource
    Energy production and peptidase activity in Eikenella corrodens (1996)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 139 (1996), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Eikenella corrodens 33EK(L), a clinical isolate, was assayed for its ability to utilise amino acids as substrates in the reduction of nitrate to nitrite. The metabolism of proline, glutamate, serine and glutamine was found to result in relatively high rates of nitrate reduction. The ability of cells to metabolise these amino acids from a variety of small peptides was also determined. E. corrodens was found to possess a relatively specific proline aminopeptidase as well as a putative carboxypeptidase activity for glutamate. Energy production in this organism appears to be via oxidative deamination of these key amino acids linked to a respiratory chain, with nitrate acting as the ultimate electron acceptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1996.tb08204.x
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  • 4
    Electronic Resource
    Electronic Resource
    The CCKA Receptor Antagonist SR 27897 Differentially Influences the Activity of A9 and A10 Dopaminergic Neurons in the Rat (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 713 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb44094.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mental health needs assessment of children and adolescents
    Amsterdam : Elsevier
    Evaluation and Program Planning 3 (1980), S. 105-109 
    Details
    ISSN: 0149-7189
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology , Sociology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0149-7189(80)90058-0
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  • 6
    Electronic Resource
    Electronic Resource
    Electric field experiments on superfluid ^3He-A
    Amsterdam : Elsevier
    Physics Letters A 55 (1975), S. 27-28 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(75)90381-3
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  • 7
    Electronic Resource
    Electronic Resource
    Growth pH and transient increases in amino acid availability influence polyglucose synthesis by Fusobacterium nucleatum grown in continuous culture (2002)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 215 (2002), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Fusobacterium nucleatum is a Gram-negative anaerobe that has been implicated in the aetiology of several diseases including periodontal diseases. Like other fusobacteria, it derives energy from the fermentation of amino acids and, in resting (non-growing) cells, this enables the organism to transport glucose and synthesise intracellular polyglucose (IP). The continued availability and fermentation of amino acids inhibits IP breakdown. We have grown F. nucleatum in continuous culture in a chemically defined medium under amino acid limitation and determined the fate of glucose during growth at steady state and during transient increases in the concentration (pulses) of serine and glutamate. When grown under steady state conditions, IP synthesis dramatically increased at culture pH values of 6.1 and 7.8 and appeared to be a result of cell stress. IP synthesis also increased when the culture was pulsed with serine or glutamate but was rapidly metabolised as the added amino acids were depleted. These results may help to explain the role of IP synthesis in response to environmental stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2002.tb11392.x
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  • 8
    Electronic Resource
    Electronic Resource
    Stable Expression of the Cloned Rat Brain Neurotensin Receptor into Fibroblasts: Binding Properties, Photoaffinity Labeling, Transduction Mechanisms, and Internalization (1994)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 63 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The study of the pharmacological, biochemical, and transduction properties of the cloned rat brain neurotensin receptor was carried out in thymidine kinase mutant fibroblasts stably transfected with the receptor cDNA. The interaction of neurotensin with transfected fibroblasts leads to a concentration-dependent stimulation of phosphatidylinositol hydrolysis and intracellular calcium. These effects are totally inhibited by the nonpeptide neurotensin antagonist SR48692. By contrast, this receptor remains unable to modulate intracellular levels of cyclic nucleotides. The transfected neurotensin receptor can be solubilized in an active form by digitonin with an identical pharmacological profile, whereas the detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propane-sulfonic acid is unable to solubilize the binding activity. The binding of iodinated neurotensin to transfected fibroblasts bearing the cloned receptor remains partly undissociated even after an acid washing step, indicating that the transfected neurotensin receptor retains the capacity to be internalized according to a temperature-dependent mechanism. Indeed, the sequestration of the neurotensin-receptor complex can be blocked by phenylarsine oxide. Finally, photoaffinity labeling experiments reveal that the cloned rat brain neurotensin receptor is expressed under two forms with molecular masses of 50 and 60 kDa. Labeling and internalization of these two proteins are totally blocked by the neurotensin antagonist SR48692.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.63010019.x
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  • 9
    Electronic Resource
    Electronic Resource
    The utilisation of arginine by oral streptococci grown glucose-limited in a chemostat (1986)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 37 (1986), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Pure cultures of 2 strains of Streptococcus milleri and one of Streptococcus mutans were grown glucose-limited at dilution rates of D= 0.1 h−1 and D= 0.3 h−1 and controlled pH of 7.0 in a chemically defined medium containing arginine levels of 0.6, 10, 33, 60 and 74 mM. Culture filtrate levels of arginine and its metabolites and glucose were determined as were cell dry weights and intracellular glycogen (IG).In S. milleri, stoichiometric conversion of up to 60 mM of arginine to citrulline and ornithine occurred, with 75% of the arginine appearing as ornithine. Similar patterns were obtained at D= 0.3 h−1, although only 30–40% of the arginine was converted to ornithine. At the 10 mM arginine level, biomass but no IG was produced while above this level, IG was also synthesised. At D= 0.3 h−1, substantial amounts of IG were detected at all arginine levels. As expected, S. mutans did not respond to increasing arginine levels and the use of this amino acid as an additional carbon and energy source with the release of ammonia in organisms such as S. milleri and Streptococcus sanguis may help to explain their dominance when growing in vitro and in vivo with S. mutans under glucose-limiting conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1986.tb01757.x
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  • 10
    Electronic Resource
    Electronic Resource
    The UK Food Supply Chain – An Ethical Perspective (1998)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Business ethics 7 (1998), S. 0 
    Details
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: “The moral issues generated by the food supply chain demand attention and analysis. There must be an ethical approach balancing profitability with the welfare of life and the conservation of the environment.” Lorice Stainer is a business ethics consultant and Visiting Fellow at Leicester University Management Centre; Alan Gully is Principal Lecturer in Business Studies, and Member for the Centre for Research in International Economics, at Middlesex University Business School; and Alan Stainer is Head of Engineering Management and Professor of Productivity and Performance Management at Middlesex University.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-8608.00109
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