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  • 1
    Electronic Resource
    Electronic Resource
    Monoamine Receptors in an Animal Model of Affective Disorder (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 55 (1990), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: After a relatively mild course of uncontrollable shocks, two distinct groups of rats can be defined in terms of their performance in learning to escape from a controllable stressor. Response-deficient (RD) rats do not learn to terminate the controllable stressor, whereas nondeficient (ND) rats learn this response as readily as do untreated control rats. The current studies were designed to determine the neu-rochemical correlates of the behavioral differences between these groups of rats. The major findings concerned postsyn-aptic β-adrenergic effects in the hippocampus of RD rats. These included an up-regulation of β-adrenergic receptors and, in parallel experiments, an increase in the sensitivity of adenylyl cyclase to stimulation by norepinephrine. There was no difference in brain levels of catecholamines between the three groups of rats. A statistically significant increase in levels of 5-hydroxytryptamine was noted in the hippocampus and hypothalamus of RD rats as compared to levels in ND rats, but no significant differences were measured between groups of rats in terms of S1 or S2 serotonergic receptor binding. These results implicate both β-adrenergic and serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1990.tb03117.x
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  • 2
    Electronic Resource
    Electronic Resource
    An Analysis of γ-Aminobutyrate Receptors and Uptake by Isolated Purkinje Cells (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 34 (1980), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: An isolated fraction of Purkinje perikarya was prepared. This fraction had [3H]GABA receptor binding and [3H]muscimol binding analogous to that reported for heterogeneous cerebellar membranes. The finding of two binding components with each ligand suggests that these components do not represent two binding sites, one presynaptic and the other postsynaptic, since both are clearly seen on purified Purkinje cell bodies. Subcellular fractionation indicates that synaptic endings and plasma membranes are enriched in GABA receptors compared with intracellular organelles. Purkinje cell bodies were also found to possess a high-affinity transport system for GABA, which was sensitive to inhibition by diaminobutyric acid (DABA) but not by β-alanine. They showed no evidence of homoexchange (the movement of label without net transport). This supports our suggestion that homoexchange is an artifact of synaptic particle formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb11259.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Uptake of the neurotransmitter candidate glutamate by glia (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 663-664 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Bulk isolated glial cells have a high affinity uptake system for y-aminobutyrate (GABA)4 that seems suitable for participation in the removal of GABA from the synaptic cleft. Autoradiography of a lobster nerve-muscle5 preparation and rat retina6 also suggests that GABA is accumulated by glial ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249663a0
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  • 4
    Electronic Resource
    Electronic Resource
    Possible relationship between glial cells, dopamine and the effects of antipsychotic drugs (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 637-638 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We undertook to localise dopamine and haloperidol binding by fractionating rabbit cortex and bovine caudate and cortex. Synaptic fractions were prepared by the method of Gray and Whittaker16, and the P2 pellet of this preparation was used as a cell-free CNS membrane fraction. Glial cell fractions ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266637a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study (1994)
    Springer
    European archives of psychiatry and clinical neuroscience 244 (1994), S. 115-125 
    Details
    ISSN: 1433-8491
    Keywords: Schizophrenic brain dysfunction ; PET in schizophrenia ; Motor dysfunction ; Cortical activation in schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia underall scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191884
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation of glial plasma membrane from a cell fraction enriched in astrocytes (1976)
    Springer
    Neurochemical research 1 (1976), S. 261-273 
    Details
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A technique for obtaining glial plasma membrane has been developed, starting with a bulk-prepared glial cell-enriched fraction from rabbit cerebral cortex. The astrocytic-enriched fraction was hand-homogenized in isotonic sucrose media, and the crude membrane fraction sedimented at 3,000g. The isolation of a membrane-enriched fraction was accomplished with sucrose density gradient centrifugation. The plasma membrane fraction was collected at the interphase between 31.5% and 25.5% sucrose. Enzymatic and electron-microscopical analyses indicated a 4–7-fold enrichment in plasma membrane, and a 15–20% contamination with microsomal and mitochondrial material. Some multilaminar membrane structures were also seen in the fraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00973773
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Receptor studies on isolated astroglial cell fractions prepared with and without trypsin (1980)
    Springer
    Neurochemical research 5 (1980), S. 459-464 
    Details
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964234
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    Paper (German National Licenses)
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