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  • 1
    Electronic Resource
    Electronic Resource
    Pulsatile secretion of pregnancy-associated plasma protein-A (PAPP-A) in non-pregnant women (1986)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 93 (1986), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. No changes in PAPP-A levels could be detected when plasma samples were obtained every second day throughout the entire menstrual cycle in three healthy women. But when measured every 30 min throughout 12 consecutive hours, in four healthy women, PAPP-A followed a pulsatile pattern which may originate in the endometrium since no PAPP-A pulses were detected in a long-term hysterectomized woman, or in two men. The pulses were not related to levels of oestradiol, progesterone, FSH or LH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1986.tb07962.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Are vaginal fluid concentrations of prolactin, α-fetoprotein and human placental lactogen useful for diagnosing ruptured membranes? (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Vaginal fluid levels of prolactin (Prl), α-fetoprotein (AFP) and human placental lactogen (hPL) were assayed to investigate their usefulness in the diagnosis of ruptured membranes. Fifty-two patients at term were divided into those with intact membranes, and those with ruptured membranes. In patients with intact membranes the concentration of all three substances was low with few exceptions. The mean vaginal concentrations of the three proteins were significantly higher in patients with ruptured membranes, but low values were also found in this group. It is concluded, that because of the overlap between the values, Prl, AFP and hPL measurements in vaginal fluid do not represent a useful advance in the assessment of rupture of the membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06469.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Circulating levels of pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotrophin (hCG) in intrauterine and extrauterine pregnancies (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotrophin (hCG) have been measured in the plasma of pregnant and non-pregnant women attending the outpatient clinic for suspicion of pregnancy. The plasma concentrations obtained were grouped into intrauterine or extrauterine pregnancies and compared with values obtained in non-pregnant patients with similar periods of amenorrhoea. Patients with ectopic pregnancies had slightly lower PAPP-A levels and significantly lower hCG concentrations than those in women with normal intrauterine pregnancies. Non-pregnant women had very low hCG and PAPP-A levels compared with those in pregnant patients. These data suggest that in patients with extrauterine pregnancies the poorly sustained ectopic trophoblast is unable to produce normal concentrations of hCG and probably PAPP-A and that the slightly diminished levels of PAPP-A in ectopic pregnancies might be derived from a decidual production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb08917.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Pregnancy-associated plasma protein-A (PAPP-A): concentration in uterine fluid and immunohistochemical localization in the endometrium (1984)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 91 (1984), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Pregnancy-associated plasma protein-A (PAPP-A) was localized immunohistochemically in the endometrium and measured in uterine fluid of non-pregnant women. The variations of PAPP-A concentrations in uterine fluid during the menstrual cycle paralleled those found in the endometrium. In patients receiving hormone therapy there was a significant correlation between the uterine fluid PAPP-A concentration and the progestogen to oestrogen potency ratio of the hormonal treatment. The presence of PAPP-A in the uterine fluid cannot simply be explained by blood contamination or cell damage. These results are interpreted as indirect evidence for an exocrine as well as an endocrine secretion of PAPP-A by the endometrium which might be influenced by hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1984.tb03698.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Therapie der dysfunktionellen uterinen Blutung (1954)
    Springer
    Archives of gynecology and obstetrics 185 (1954), S. 122-127 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurden bei 6 Patienten an Hand von Vaginalabstrichen nachShore und Pregnandiolausscheidungskurven, die Resorption und Wirkung einer neueren, zur Therapie der uterinen dysfunktionellen Blutungen bestimmten Mischspritze, enthaltend 10 mg Oestradiol und 200 mg Progesteron als Kristallsuspension, beurteilt. Dabei ergaben sich den physiologischen, bis heute bekannten Werten, sehr naheliegende Zahlen. Bei 32 Patienten kam die gleiche Mischspritze im klinischen Versuch zur Anwendung. Mit einer Ausnahme wurde in allen Fällen eine zufriedenstellende Blutstillung erzielt. Dies mag gegenüber der bis jetzt bekannten Oestrogentherapie aus finanziellen, aber auch Gründen der besseren Verträglichkeit als Vorteil gelten. Bei der histologischen Untersuchung des Endometriums bei 19 Patienten wurde der Zeitpunkt des Beginnes, der durch die Injektion verursachten sekretorischen Umwandlung auf den 6.-9. Tag nach der aus Injektion festgelegt. Am 9.-20. Tag nach der Injektion trat bei den nichtcurettierten und nichtoperierten Patienten eine Abbruchblutung ein (13 Patienten). 11 davon konnten im späteren Verlauf ohne weiteren chirurgischen Eingriff als geheilt entlassen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00976110
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Progesterone dependence and extratrophoblastic origin of pregnancy-associated plasma protein-A (PAPP-A) in early pregnancy (1986)
    Springer
    Archives of gynecology and obstetrics 237 (1986), S. 109-116 
    Details
    ISSN: 1432-0711
    Keywords: PAPP-A ; hCG ; RU486 ; Abortions ; Moles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pregnancy-associated plasma protein-A (PAPP-A) is a macromolecular glycoprotein produced in increasing concentration as pregnancy advances. PAPP-A is not specific to pregnancy since measurable levels have been found in non-pregnant females and in males. In non-pregnant females, PAPP-A is probabely produced by the endometrium. The origin of PAPP-A in pregnant women is still controversial. In-vitro trophoblast and decidual explants both produce PAPP-A. So far, it is not known if the same applies to the in-vivo situation and to what extent these two tissues contribute to the circulating levels of PAPP-A. This study compares the circulating concentrations of PAPP-A and β-hCG and progesterone in different pathological situations. In hydatidiform moles, β-hCG levels are very high demonstrating an intense trophoblastic activity, whereas PAPP-A levels remain in the normal range. With spontaneous abortions, β-hCG levels decline to very low values whereas PAPP-A continues to increase. These observations furnish indirect evidence for a major contribution to circulating PAPP-A levels by extratrophoblastic sites. Furthermore, PAPP-A levels decrease after administration of an antiprogesterone (RU486) either in-vivo or in-vitro. This is considered as a proof that PAPP-A levels in early pregnancy are progesterone dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02133854
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    Paper (German National Licenses)
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