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Digitale Medien

The dopamine D3-receptor: A postsynaptic receptor inhibitory on rat locomotor activity (1993)

Waters, N. ; Svensson, K. ; Haadsma-Svensson, S. R. ; [weitere]

Springer

Journal of neural transmission 94 (1993), S. 11-19

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Details

ISSN: 1435-1463

Schlagwort(e): Dopamine ; release ; D 3 receptor ; locomotor activity ; rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We report on the pharmacological effects of the 20 fold D 3 vs. D 2 dopamine receptor preferring compound U 99194 A. It is shown that U 99194 A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the striatum or the nucleus accumbens significantly. The data do not support any direct agonist action of U 99194 A at dopamine receptors. It is suggested that U 99194 A can antagonise a population of postsynaptic dopamine receptors involved in the suppression of some aspects of psychomotor activity. These postsynaptic receptors presumably belong to the D 3 receptor subtype.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01244979

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