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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 279 (1976), S. 155-158 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The properties of asymmetric nuclear matter withα=(ρ n-ρ p)/ρ≦ 0.4 are studied within the framework of the lowest order Brueckner theory, atk F =1.35fm−1 (ρ=0.166 fm−3). TheK-matrix is calculated self-consistently from the Reid soft core nucleon-nucleon interaction. In the case ofρ n ≠ρ p theK-matrix contains a term which does not conserve the total isospin of the interacting unlike-nucleon pair. At α=0.4 the relative magnitude of this term is of the order of 1 %. The symmetry energy is found equal to 23.1 MeV.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 126 (1994), S. 17-26 
    ISSN: 0942-0940
    Keywords: Oncogenes ; suppressor genes ; cell culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human malignant gliomas are frequently associated with loss of gonosomes and chromosomes 13, 17, and 22. Their progression from anaplastic glioma to glioblastoma is marked by additional loss of chromosome 10. In addition, structural and numerical aberrations of chromosome 7 are frequently found. We report on the karyotypes of a series of 20 human gliomas of which 11 were analysed as established cell lines; 9 cases were investigated in early culture, 5 of which later also became established lines. In addition to the frequently reported overrepresentation of chromosome 7, four cell lines with polysomy for chromosome 22 were seen. A high incidence of structural chromosomal aberrations was present in early cultures as well as in cell lines after various in vitro passages. We found that the general characteristics of karyotypic aberrations found in early cultures or direct preparations of dispersed tumour material were reflected in the pattern of aberrations present in cell lines at much later time points. Thus it appears as if no systematic changes can be attributed to long-term cultures. Suspicious losses of chromosomes 14, 18, and 19 or gain of chromosome 22 indicate that individual cases may have originated due to other mechanisms than the ones already hypothesized, i.e., different suppressor genes or amplification of genes other than the EGF-R-gene. None of the established cell lines had a genomic rearrangement of c-erbB 1, c-erbB 2 or of the p 53 gene.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The oxidation behaviour of binary Fe-Cr alloys containing 10 and 20 mass % Cr,respectively, was studied in Ar-20%O2, Ar-7%H2O and in Ar-4%H2-7%H2O at temperaturesbetween 800 and 1050°C. Thermogravimetric analyses in combination with analytical studies usingSEM/EDX and Raman Spectroscopy revealed, that in atmospheres in which water vapor is thesource of oxygen, Cr exhibits a higher tendency to become internally oxidized than in the Ar-O2gas. Contrary to previous studies which showed the presence of water vapor to affect transportprocesses in the surface oxide scale, the present results reveal that the presence of water vapor alsoaffects the transport processes in the alloy. The enhanced internal oxidation, which is likely theresult of water vapor increasing the solubility and/or the diffusivity of oxygen in the alloy, explainsthe frequently observed effect that Fe(Ni)Cr alloys with intermediate Cr contents (e.g. 10-20%,depending on temperature) exhibit protective oxidation in dry gases but breakaway type oxidationin steam. The temperature dependence of the change from protective to non-protective behaviour inAr-H2O differs quantitatively, but not qualitatively from that in Ar-O2
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 358 (1997), S. 230-232 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The oxidation of chromium and chromium based alloys with yttria additions of 0.5 to 4 wt.%, processed by mechanical alloying, was investigated. Additionally, the effect of milling time on the oxidation behavior was examined. The samples were oxidized at 950°C in air. Weight changes, optical microscopy and SEM were utilized to characterize the oxidation behavior. Although it appeared that the presence of yttria reduced the oxidation rates significantly, the exact concentration of yttria was far less essential for the oxidation properties than the yttria distribution.Therefore the oxidation resistance of ODS (oxide dispersion strengthened) alloys strongly depends on the exact manufacturing process.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 270 (1959), S. 28-28 
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1335
    Keywords: Gynecological tumors ; Cellular heterogeneity in culture ; Chemosensitivity ; Proliferation assay ; Reproducibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Procedures for the in vitro determination of the drug-induced inhibition of mammary and ovarian carcinoma cell growth were established. In monolayer cultures derived from advanced tumors, separation of epithelial carcinoma cells from concomitant cells of fibroblast-like or mesothelial appearance was achieved by differential trypsinization. The carcinoma cell character of the stock cultures was verified by chromosome analyses showing a high degree of aneuploidy for the epitheloid cell lines and euploidy for cells of apparently mesenchymal origin. When cultured carcinoma cells were injected in nu/nu mice, the tissue and cell cultures obtained from the heterotransplantation tumors closely resembled the original tumors and cell cultures in morphology, karyotype, and expression of tumor markers. The action of carcinostatic drugs in the logarithmic phase of the carcinoma cell proliferation was tested by kinetics experiments in multiple experimental cultures. In cell proliferation assays based on cell counts the 50% inhibition dose (ID50) of the drug effects was determined from the dose-response curves. Comparison of the ID50s revealed highly differential effectiveness of the drugs examined. The inhibitory effects were reproducible, rendering the procedures used suitable for testing the chemosensitivity of newly explanted gynecological carcinoma cells by proliferation assays.
    Type of Medium: Electronic Resource
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