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  • 1
    Electronic Resource
    Electronic Resource
    Mononuclear Cell Factors that Inhibit Fibroblast Collagen Synthesis (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 18 (1983), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Supernatants harvested from peripheral blood mononuclear cells (PBMC) incubated either with the non-specific mitogen phytohaemagglutinin-P (PHA) or with the specific antigen tuberculin purified protein derivative for 72 h decreased collagen synthesis by dermal fibroblasts. PHA-induced mononuclear cell factors (PHA-MCF) responsible for decreases in collagen synthesis by dermal fibroblasts were localized by column chromatography on Sephacryl S-200 to fractions of 30,000-60,000 daltons. Proteolytic enzymes destroyed the activity of PHA-MCF, but after incubation with neuraminidase some activity of these factors remained, The activity of PHA-MCF was not inhibited by incubation with the monosaccharides L-fucose, L-rhamnose. N-acetylglucosamine, and α-melhyl-D-mannoside but was partially destroyed by heating at 80°C for 10 min. The factors were not mitogenic to PBMC. These factors did not appear to resemble any previously characterized factors produced by non-adherent mononuclear cells. The mechanism by which these factors decreased fibroblast collagen synthesis appeared complex. There was no detectable increase in the release of collagenasc by fibroblasts, nor was a cytotoxic effect apparent. Increased PGE2 production by fibroblasts could not be related to the factor-induced decrease in fibroblast collagen synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1983.tb00835.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Long-term Corticosteroid Therapy on Monocyte Chemotaxis in Man (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 11 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influence of prednisolone on monocyte chemotactic activity in vitro at prednisolone concentrations comparable with those achieved in man following oral dosage has been investigated. Chemptactic activity of monocytes from each of sixteen normal subjects was suppressed by concentrations of prednisolone as low as 25 ng/ml (suppression of chemotaxis, 20%). Maximal suppression occurred at 100 ng/ml (suppression of chemotaxis, 48%) and no significant increase in suppression was produced by increasing the concentration to 200 ng/ml (suppression of chemotaxis, 53%). In contrast, monocytes isolated from ten patients receiving corticosteroid therapy showed no significant suppression of chemotactic activity when exposed to these concentrations of prednisolone, even though they exhibited a normal ability to respond to a chemotactic stimulus. The lack of suppression of monocyte chemotaxis in patients receiving corticosteroid therapy is unexplained, but may represent a change in the circulating monocyte or lymphocyte populations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00242.x
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  • 3
    Electronic Resource
    Electronic Resource
    Mononuclear Cell Factors that Inhibit Fibroblast Collagen Synthesis (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 18 (1983), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral blood mononuclear cells (PBMC) incubated either with phytohaemagglutinin-P (PHA) under serum-free conditions or with tuberculin purified protein derivative in the presence of 5% human blood group AB serum released into the culture medium factors that decreased collagen synthesis by dermal fibroblasts. These factors were first detected after incubation of PBMC with PHA for 24 h and were produced by non-adherent cells. The decrease in collagen synthesis was observed despite changes in conditions of fibroblast culture, the addition of a cross-linking inhibitor, and the use of different fibroblast cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1983.tb00834.x
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  • 4
    Electronic Resource
    Electronic Resource
    Factors Influencing Disease Expression in Hemochromatosis (1996)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nutrition 16 (1996), S. 139-160 
    Details
    ISSN: 0199-9885
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.nu.16.070196.001035
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  • 5
    Electronic Resource
    Electronic Resource
    INFLUENCE OF ALCOHOL AND CAFFEINE CONSUMPTION ON CAFFEINE ELIMINATION (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Ten healthy male volunteers were each studied on four separate occasions to assess the role of regular caffeine and alcohol intake on caffeine elimination. Antipyrine disappearance was also studied as an established quantitative test of hepatic microsomal function.2. Regular caffeine intake in high doses for 1 week failed to alter either antipyrine or caffeine pharmacokinetics.3. In contrast, alcohol intake of 50 g/day significantly prolonged caffeine half-life by 72% (P〈0.005) and diminished caffeine clearance by 36% (P〈0.0005). However, antipyrine kinetics were unaltered.4. These results demonstrate that alcohol, in amounts commonly consumed, is a strong inhibitor of caffeine metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb02414.x
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  • 6
    Electronic Resource
    Electronic Resource
    DOSIMETRY IN SUPPORT OF WHOLESOMENESS STUDIES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food processing and preservation 3 (1979), S. 0 
    Details
    ISSN: 1745-4549
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Interest in dosimetry procedures in the context of a large-scale processing situation exceeds the purely documentary aspects of this report. The numerous combinations afforded by the various types, strengths and configurations of irradiation sources and the possibilities for various conveyors and other facility design factors impacting on irradiation logistics render a completely general treatment of dosimetry procedures in such instances almost impossible. While the exact combination of these various factors represented by the irradiation facilities at NARADCOM may be duplicated nowhere else, the dosimetry procedures documented in this report offer both experience and solutions that might be more generally useful. Therefore, this report complements and supplements more general discussions found in the literature and cited in the text.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4549.1979.tb00578.x
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  • 7
    Electronic Resource
    Electronic Resource
    Is All Genetic (Hereditary) Hemochromatosis HLA-Associated (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 526 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb55489.x
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  • 8
    Electronic Resource
    Electronic Resource
    Screening for Hemochromatosis (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 526 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb55512.x
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  • 9
    Electronic Resource
    Electronic Resource
    Idiopathic hemochromatosis: demonstration of homozygous-heterozygous mating by HLA typing of families (1982)
    Springer
    Human genetics 〈Berlin〉 60 (1982), S. 352-356 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In five families with idiopathic (hereditary) hemochromatosis, clinical and biochemical expression of the disease occurred in offspring of probands, suggesting an autosomal dominant mode of inheritance. However, HLA typing of subjects indicated that a homozygous-heterozygous mating almost certainly had occurred in four of the five families, resulting in homozygous offspring. Thus, in these families inheritance of the hemochromatosis trait was best explained in terms of an autosomal recessive or intermediate mode of inheritance. This study demonstrates the value of HLA typing in identifying homozygous-heterozygous matings in hemochromatosis families.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569217
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  • 10
    Electronic Resource
    Electronic Resource
    Fine mapping of a human chromosome 6 ferritin heavy chain pseudogene: relevance to haemochromatosis (1991)
    Springer
    Human genetics 〈Berlin〉 88 (1991), S. 175-178 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have used a somatic cell hybrid regional mapping panel for the short arm of chromosome 6, linkage analysis and a population study to map in detail a previously described ferritin heavy chain pseudogene sequence on chromosome 6. Our results show that this sequence maps to the short arm of chromosome 6 centromeric to the glyoxylase locus. The ferritin pseudogene locus is thus distant from the locus for the iron storage disease haemochromatosis, confirming previous evidence that this sequence is not a candidate for the haemochromatosis gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206067
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