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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 7 (1984), S. 0 
    ISSN: 1460-2695
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Maschinenbau
    Notizen: In order to study creep-fatigue interactions under multiaxial stress states, both push-pull and reversed torsion low-cycle fatigue tests were carried out using an austenitic stainless steel, SUS 304, at 923 K in air. From the tests, it is concluded that the hold-times introduced at the peak strain reduce low-cycle fatigue lives in the push-pull mode, but in the torsional mode they were not so harmful. This difference in the hold-time effect is discussed from considerations of crack formation and propagation and the stress amplitude applied to the specimen.Both maximum principal strain range, Δε1, and the von Mises' equivalent strain range, Δεeq, provide a nearly adequate comparison base for the assessment of biaxial low-cycle fatigue lives in tests without strain hold-time but are inadequate for hold-time tests. An equivalent stress range, Δσ*, which includes the effect of the stress parallel to the fatigue crack and which was previously proposed by the authors for no hold-time tests, is applied to the hold-time tests in the biaxial stress state. It is found that Δσ* is a good parameter for the correlation of biaxial low-cycle fatigue data in both no hold-time and hold-time tests.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 9 (1986), S. 0 
    ISSN: 1460-2695
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Maschinenbau
    Notizen: This paper describes the cyclic strain hardening behaviour and dislocation structures of material in biaxial low cycle fatigue at elevated temperatures. In this study, push-pull, reversed torsion and combined push-pull/reversed torsion tests were carried out using a type 304 stainless steel in air. While there was no significant difference between the cyclic stress amplitudes in the push-pull and reversed torsion tests on a von Mises' base, combination tests exhibited a 40% increase in stress amplitude. Most of the dislocations in the first two types of test adopted ladder or maze structures, while in the later case cells were found. Changing the loading mode at a certain cycle, for example, from push-pull to reversed torsion, revealed that stress amplitude depended mainly on the concurrent applied strain mode and furthermore, that the strain mode before the interchange had little or no effect on the stress amplitude after the interchange. Tests were also performed in order to examine how prestrained material hardened in the three different loading modes, with the following results: prestrained material in push-pull or in reversed torsion exhibited an anisotropic stress response, while the material in the combined tests exhibited an isotropic response. These cyclic responses are discussed in connection with the dislocation structure.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1600-079X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Our previous work showed that melatonin (N-acetyl-5-methoxytryptamine) inhibits proliferation of the human endometrial cancer cell line, Ishikawa, which is estrogen receptor-positive. The aim of the present study was to determine whether Ishikawa cells possess membrane melatonin receptors. Binding of the radioligand 2-[125I]-iodomelatonin to membrane preparations obtained from Ishikawa cells was detectable, saturable and stable. Scatchard analysis revealed that the dissociation constant (Kd) of the binding sites was 179.0 pm (similar to that of the MT2 [Mel1b] melatonin receptor subtype), and that the concentration (Bmax) of the binding sites was 12.9 fmol/mg protein. Luzindole, a selective MT2 melatonin receptor antagonist, significantly suppressed binding of 2-[125I]-iodomelatonin at all concentrations tested (10−8 to 10−4 m). These results suggest that the MT2 melatonin receptor subtype is present in the membranes of Ishikawa cells, and that the antiproliferative effect of melatonin on Ishikawa cells is mediated via the MT2 receptor. This may have implications for the use of melatonin in endometrial cancer therapy.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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