ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco-ε-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinningapparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property,tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffoldwasn’t fabricated well in the condition of 4% gel concentration. In general, the thickness level ofmicrofibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showedstronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%,10% and 12.5% scaffolds were analyzed in both directions: circumferential direction andlongitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse toexamine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds.Both shows very similar degradation rates, but the aspect in tissue in-growth was different. Inconclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold forcardiovascular tissue engineering
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.321.pdf
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