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Intrasynovial levels of sulphated glycosaminoglycans and autoantibodies to type II collagen in rheumatoid arthritis: a correlative analysis (1993)

Karopoulos, C. ; Rowley, M. J. ; Handley, C. J.

Springer

Rheumatology international 13 (1993), S. 15-20

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ISSN: 1437-160X

Keywords: Collagen antibodies ; Sulphated glycosaminoglycans ; Rheumatoid arthritis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary It is uncertain whether the autoantibodies to type II collagen that occur frequently in the serum and synovial fluid of patients with rheumatoid arthritis (RA), but rarely in other articular diseases, are primary or secondary to cartilage damage. Hence, we measured antibodies in synovial fluid from patients with RA and other articular disease and related these to the concentration of sulphated glycosaminoglycans, as a measure of ongoing cartilage catabolism. Synovial fluids from 42 patients with RA and 30 patients with other articular diseases were studied. We found that levels of antibodies to native and denatured collagen were significantly higher in RA than in all other articular diseases, whereas concentrations of sulphated glycosaminoglycans were similar. The absence of any correlation between levels of sulphated glycosaminoglycans and antibodies to collagen weighs against the occurrence of such antibodies in RA as a secondary effect of cartilage damage.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00290329

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Biochemical changes in cervical mucus-factor infertility (1985)

Lutjen, P. J. ; Handley, C. J. ; de Witt, M. T. ; [et al.]

New York, NY : Wiley-Blackwell

Gamete Research 12 (1985), S. 265-274

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ISSN: 0148-7280

Keywords: cervical mucus ; infertility ; sialic acid ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Cervical-factor infertility has generally been attributed to the presence of antispermatozoal antibodies in the secretions of the uterine cervix, despite the fact that the incidence of sperm-specific antibodies in these women is generally low. We report here a modification in the structure of the cervical mucus of patients with a diagnosed cervical factor. Cervical mucus from patients with a cervical factor of nonimmunological origin, collected during the periovulatory phase of the menstrual cycle, had (1) a significant decrease in the content of glycosidically bound sialic acid and (2) an increased ability to act as an acceptor for sialic acid from cytidine-5′-monophospho-N-acetylneuraminic acid (CMP-sialic acid) when incubated with an exogenous sialyltransferase; in comparison to mucus from normal fertile women. Both siaiyltransferase and fucosyltransferase activities were detected in cervical mucus, but there was no difference between fertile normal and cervical-factor patients using the assays described. These results reinforce a possible role for sialic acid residues and their associated glycosyltransferases in the regulation of spermatozoal-cervical mucus interaction.

Additional Material: 4 Tab.