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  • 1
    Electronic Resource
    Electronic Resource
    Targeting of neoglycoprotein-drug conjugates to cultured human embryonal carcinoma cells (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 126-130 
    Details
    ISSN: 1432-1335
    Keywords: Neoglycoprotein-drug conjugates ; Human embryonal carcinoma cells ; Targeting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fluorescent neoglycoproteins were used to screen for the presence and sugar specificities of cell surface lectins in two human embryonal carcinoma cell lines. Efficient labeling correlated with extent of lectin-mediated uptake of neoglycoproteins, as measured by inhibition of DNA synthesis by drug-neoglycoprotein conjugates. These conjugates contain covalently linked carbohydrate moieties on the carriers to render them accessible to the membrane lectins, most effectively galactosides and α-glucosides. They furthermore contain chemically linked cytotoxic drugs (etoposide, cis-diamminedichloroplatinum II and methotrexate) which are intracellularly released after lysosomal breakdown of the carrier, as indicated by the effect of leupeptin. Sugars can confer a greater than 10-fold increase in cytotoxic capacity to the nonglycosylated carrier-drug conjugate, nearly reaching the level of toxicity of the freely diffusible drug. Two different neoglycoproteins, reacting with independently targeted membrane lectins, were shown to be useful in a model for combination chemotherapy. These results therefore suggest potential usefulness of custom-made glycosylated carriers in the targeting of therapeutic agents to human embryonal carcinoma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391433
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  • 2
    Electronic Resource
    Electronic Resource
    Basic flow structure in saccular aneurysms: A flow visualization study (1987)
    Springer
    Heart and vessels 3 (1987), S. 55-65 
    Details
    ISSN: 1615-2573
    Keywords: Cerebral aneurysm ; Hemodynamics ; Rupture ; Aneurysm growth ; Thrombosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Basic flow patterns were investigated in a set of glass aneurysm models by means of flow visualization methods. Dye injection and streaming double refraction were used to visualize flow. The circulation inside lateral aneurysms arising at a 90° angle from a straight parent conduit could not be visualized by the dye-injection technique but could be demonstrated by streaming double refraction. The inflow was seen to arise from the downstream lip of the orifice and to project to the dome of the aneurysm. Backflow to the parent conduit took place along the walls of the aneurysm. In aneurysms located at bifurcations, flow characteristics depended on the geometry of the bifurcation and the flow ratio between the branches. Relatively little intra-aneurysmal flow was demonstrated in side branch-related aneurysms arising distal to an asymmetric 90° bifurcation of the type encountered at the junction of the internal carotid and posterior communicating arteries. Stagnation of flow at the neck and little intra-aneurysmal circulation were found with terminal aneurysms of the basilar bifurcation type if the outflow through the branches was symmetric. With asymmetric outflow, however, or if the axis of the aneurysm did not coincide with that of the afferent vessel, an active rotation developed in these aneurysms. The size of the aneurysm had no influence on the basic pattern of intra-aneurysmal circulation. The use of pulsatile perfusion did not significantly alter the basic flow patterns observed with steady flow. Locally disturbed laminar flow was observed in certain models at physiological Reynold's numbers, but there were no signs of fully developed turbulence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058520
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  • 3
    Electronic Resource
    Electronic Resource
    Hemodynamic stress in terminal saccular aneurysms: A laser-doppler study (1988)
    Springer
    Heart and vessels 4 (1988), S. 162-169 
    Details
    ISSN: 1615-2573
    Keywords: Cerebral aneurysm ; Experimental aneurysm ; Hemodynamic stress ; Laser-Doppleranemometer ; Wall shear stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The flow conditions and the related stresses in glass and silastic model aneurysms located at bifurcations were quantitatively determined by means of laser-Doppler-anemometry. The flow velocities in straight terminal models with the aneurysm forming an extension of the afferent vessel were unstable if the outflow through the branches of the bifurcation was balanced. Average flow velocities in the fundus were small, but irregular flow fluctuations of high amplitudes were observed. Asymmetrical outflow through the branches of the bifurcation induced a rotatory intra-aneurysmal circulation from the dominant to the subordinate branch. The circulation in angled terminal aneurysms with the aneurysmal axis at a 45° angle to the plane of the bifurcation was a vortex caused by the eccentric inflow from the afferent vessel. Maximum flow velocities measured in the center plane of the angled terminal aneurysms were in the range 50%–80% of the axial velocity in the afferent vessel. The present results indicate that the geometrical relation between aneurysm and parent vessels is the primary factor governing the intra-aneurysmal flow pattern. The elasticity of the models did not affect the average flow velocities, but the intra-aneurysmal pulse wave was damped in elastic models. On the basis of the measured velocity gradients near the walls, maximum shear stresses on the wall of a typical human terminal aneurysm were estimated to be in the order of 50 dyne/cm2 (5 Pascal), a value that is similar to the shear stresses that occur at the flow divider of a cerebral artery bifurcation. This is based on absolute flow velocity measurements in patients [8, 13].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058429
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  • 4
    Electronic Resource
    Electronic Resource
    Strength, elasticity and viscoelastic properties of cerebral aneurysms (1989)
    Springer
    Heart and vessels 5 (1989), S. 41-46 
    Details
    ISSN: 1615-2573
    Keywords: Cerebral aneurysm ; Pathogenesis ; Growth ; Viscoelastic material ; Stress relaxation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue strength and stiffness of cerebral aneurysm walls obtained intraoperatively or at autopsy were evaluated by uniaxial strain/stress measurements. For comparison, corresponding measurements were also made on autopsy specimens of intracranial arteries. The maximum stress that the aneurysm tissue could tolerate, the yield stress, was found to be slightly lower than in arteries, which is likely due to the content of immature forms of collagen. The material stiffness, as determined by division of the yield stress by the corresponding strain, was also smaller in aneurysms than in arteries. The stress resistance of aneurysms and arterial tissue decreased over a period of several hours. The relaxation curves were found to be identical in aneurysms and arteries. The stress tolerated by aneurysm walls was found to be in the range of the stress that is imposed in vivo by the blood pressure. Arteries resisted stresses corresponding to pressures 5–10 times higher than physiological values. It is suggested that the balance of tissue strength and the stress imposed by the blood pressure is causally related to aneurysm growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058357
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  • 5
    Electronic Resource
    Electronic Resource
    Sizing of Submicron Aerosol Particles by the Whisker Particle Collector Method (1988)
    Weinheim : Wiley-Blackwell
    Particle and Particle Systems Characterization 5 (1988), S. 174-178 
    Details
    ISSN: 0934-0866
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Samples of an alumina powder aerosol were collected on whisker particle collectors and analysed following an improved evaluation scheme which allows the empirical size distribution to be corrected for the effect of a non-uniform collection efficiency. The measurement results are given in terms of log-normal distribution functions. Some ambiguity was encountered in interpreting particle aggregates that were found on the whisker collectors. By including the results of laser light-scattering experiments in the size analysis, this ambiguity was removed. Advantages and disadvantages of the whisker collector concept compared with light-scattering methods are discussed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ppsc.19880050404
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  • 6
    Electronic Resource
    Electronic Resource
    Morphological and biomechanical aspects of Al2O3 ceramic joint replacement. Experimental results and design considerations for human endoprostheses (1975)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 9 (1975), S. 177-188 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Four different acetabular replacement designs and 2 femoral head replacement designs made out of high density alumina ceramic have been tested in sheep with postoperative survival times of up to 11 months (Frialit 99: Al2O3 99.6%, MgO 0.4%).It can be concluded from these experiments that a cement free implantation technique with alumina requires a primary rigid fixation of the implant to bone, with the possibility for new bone growth along the ceramic and into grooves and macroscopic holes for further interdigitation. Three different solutions for the acetabular component can be recommended for human application.In addition, an all ceramic femoral prosthesis has been tested for bending strength in its neck region. Twenty prostheses have been fractured, all of which showed values for bending strength far higher than the physiological neck fracture level (900 kp/cm2). The present state of development of all ceramic prostheses is discussed. Up to now, the development of fibrous tissue between the bone and the ceramic implant has caused reservations with human implantation. The direct definite anchorage problem has to be resolved first.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820090421
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of calcium aluminate phases in cements by aluminum-27 MAS NMR spectroscopy (1993)
    s.l. : American Chemical Society
    Inorganic chemistry 32 (1993), S. 1013-1027 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00058a043
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  • 8
    Electronic Resource
    Electronic Resource
    Novel Coordination Pattern of Dithiophosphorus Ligands. Crystal and Molecular Structure of (Diphenylphosphinodithioato)phenyltellurium(II), PhTeS2PPh2. Supramolecular Association through Monodentate Biconnective Dithiophosphorus Ligands (1994)
    s.l. : American Chemical Society
    Inorganic chemistry 33 (1994), S. 1253-1254 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00085a007
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  • 9
    Electronic Resource
    Electronic Resource
    Crystal and Molecular Structure of Bis(diphenyldithiophosphinato)lead(II), .infin.1[Pb(S2PPh2)2], a New Type of Polymer Associated through Pb.cntdot..cntdot..cntdot.S Secondary Interactions (1994)
    s.l. : American Chemical Society
    Inorganic chemistry 33 (1994), S. 1695-1699 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00086a020
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  • 10
    Electronic Resource
    Electronic Resource
    Multiphoton mass spectrometry (1983)
    s.l. : American Chemical Society
    Accounts of chemical research 16 (1983), S. 355-360 
    Details
    ISSN: 1520-4898
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ar00093a007
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