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  • 1
    Electronic Resource
    Electronic Resource
    Intrauterine Transfusion unter Ultraschallkontrolle (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 930-932 
    Details
    ISSN: 1432-1440
    Keywords: Erythroblastosis fetalis ; intrauterine transfusion ; ultrasound in obstetrics ; B-scan (brightness modulation) ; Rh-Inkompatibilität ; intrauterine Transfusion ; Ultraschall in der Geburtshilfe ; Schnittbild-Technik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei zwei an einer Rh-Inkompatibilität schwer erkrankten Feten wurde viermal unter hauptsächlicher Benutzung des Ultraschall-Schnittbildgerätes Vidoson 635 (Fa. Siemens) eine intrauterine Transfusion durchgeführt. Die Transfusionsnadeln waren in allen Fällen auf dem Schnittbildmonitor klar erkennbar und konnten bis zur gewünschten Eindringtiefe zielgenau in die fetale Peritonealhöhle gelegt werden. Die Anwendung von Röntgenstrahlen konnte erheblich reduziert werden. Die beschriebene Methode scheint insbesondere für die ungünstigen dorso-anterioren Lagen des Feten geeignet zu sein.
    Notes: Summary In two cases of severe erythroblastosis fetalis, intrauterine transfusion was performed four times under control of ultrasonic fast B-scan motion picture (Vidoson 635 manufactured by Siemens West-Germany). The transfusion needles were in all cases clearly recognizable on the B-scan monitor und could be directed without difficulty into the fetal peritoneal cavity to the wanted depth. By using this technique X-ray exposure was quite reduced. The technique described appears quite suitable in the case of the unfavorable dorso-anterior positions of the fetus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487926
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  • 2
    Electronic Resource
    Electronic Resource
    Intrauterine Transfusion unter Ultraschallkontrolle (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 1116-1116 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486860
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  • 3
    Electronic Resource
    Electronic Resource
    Rate of chromosomal aberrations in prenatally detected hydrops fetalis and hygroma colli (1989)
    Springer
    Human genetics 〈Berlin〉 84 (1989), S. 81-82 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chromosome analyses were carried out in a series of 775 fetuses with morphological abnormalities diagnosed by ultrasound. Among these cases, 57 demonstrated non-immune hydrops fetalis with hygroma colli (group 1) and a further 116 non-immune hydrops fetalis without hygroma colli (group 2). Different chromosome abnormalities were found in 54.5% of cases of group 1 where chromosome analyses could be performed, and in 27.6% of cases of group 2. The most common aberrations were monosomy X and trisomy 21.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210678
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosomal findings in fetuses with prenatally diagnosed cysts of the choroid plexus (1992)
    Springer
    Human genetics 〈Berlin〉 89 (1992), S. 301-304 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Choroid plexus cysts were diagnosed in 25 out of 823 fetuses with prenatally diagnosed abnormalities (growth retardation/malformations). Among these, 5 revealed a chromosomal disorder (4 cases with trisomy 18 and one case with a translocation trisomy 21). Additional abnormalities, such as growth retardation, holoprosencephaly, hydrocephalus and club foot, were found in 6 out of the 20 fetuses with no chromosomal abnormality. All fetuses with a chromosomal disorder revealed further typical prenatally recognizable abnormalities. Our observation indicates that prenatally diagnosed choroid plexus cysts should be considered as an indication for prenatal chromosomal diagnosis, although the risk of there being an underlying chromosomal disorder is low in cases with no additional abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220545
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  • 5
    Electronic Resource
    Electronic Resource
    Homozygous α-thalassaemia and hypospadias – common aetiology or incidental association? (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 217-220 
    Details
    ISSN: 1432-1076
    Keywords: Key wordsα-Thalassaemia ; Hb Bart's ; Hydrops fetalis ; Genital ambiguity ; Intrauterine transfusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fetuses with homozygous α-thalassaemia develop Hb Bart's hydrops fetalis syndrome, which usually leads either to abortion or fetal/neonatal death. We report diagnosis, intrauterine transfusion therapy, neonatal intensive care management and long-term follow-up of a Vietnamese infant who survived Hb Bart's hydrops fetalis syndrome. During the first 2 years the child had normal development. In addition, the patient exhibited penoscrotal hypospadias. Despite a thorough endocrinological work-up the aetiology of genital ambiguity could not be elucidated. A review of the literature showed an association of homozygous α-thalassaemia and hypospadias in all surviving male children, suggesting a common aetiology for both entities. Conclusion On the basis of our findings, we speculate that an unknown gene on chromosome 16 responsible for genital formation is altered in homozygous α-thalassaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051053
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  • 6
    Electronic Resource
    Electronic Resource
    Neurodevelopmental outcome after intrauterine red cell transfusion for Parvovirus B19-induced fetal hydrops (2002)
    Oxford, UK : Blackwell Science Ltd
    BJOG 109 (2002), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess long term neurodevelopmental outcome of children after intrauterine intravascular red cell transfusion (IUT) for Parvovirus B19-induced fetal hydrops.Design Data of study children were investigated retrospectively. Neurodevelopmental evaluation was performed by appropriate standard tests (Griffiths, Snijders–Oomen, Kaufmann Assessment Battery for Children tests).Setting Tertiary care university teaching hospital.Sample Twenty children who had Parvovirus-induced fetal hydrops and intrauterine transfusion of packed red blood cells (IUT).Methods Retrospective chart analysis and standard neurodevelopmental testing.Main outcome measures Developmental quotient (DQ) and intelligence quotient (IQ) according to the age at testing.Results Twenty survivors of Parvovirus B19-induced fetal hydrops successfully treated by IUT were followed until 13 months to nine years of age. On clinical follow up, no neurologic sequelae were evident. Neurodevelopmental scores of all children ranged within two standard deviations of a normal population (median 101, range 86–116) and exceeded one standard deviation in three children. There was no significant neurodevelopmental delay.Conclusion Children having survived successful IUT for Parvovirus B19-induced fetal anaemia and hydrops have a good neurodevelopmental prognosis. Our results support the use of IUT for correction of Parvovirus B19-induced fetal anaemia and subsequent hydrops.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-0528.2002.02118.x
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  • 7
    Electronic Resource
    Electronic Resource
    The cytological spectrum of the monocytoid B-cell reaction: recognition of its large cell type (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 23 (1993), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To analyse the cytological features of benign monocytoid B-cells, we investigated, histologically and immunohisto-chemically, 78 reactive lymphadenopathies expressing monocytoid B-cell reactions. Within a broad cytological spectrum of reactive monocytoid B-cells, two cytological types can be recognized: 1 the common type composed of medium-sized cells with irregular or bean-shaped nuclei and inconspicuous nucleoli, and 2 the large cell type composed of cells considered to represent large transformed monocytoid B-cells, with less pleomorphic round nuclei with vesicular chromatin and moderately basophilic, prominent nucleoli. In between these variants transitional forms showing evolution to large transformed monocytoid B-cells occurred. While monocytoid B-cell reactions in 70.5% of all cases were composed predominantly of the common type of monocytoid B-cells, in 29.5% of cases the large transformed cells prevailed. The two distinctive cytological types of reactive monocytoid B-cells, seem to have their neoplastic counterparts in monocytoid B-cell lymphoma, including its large cell variant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1993.tb00490.x
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  • 8
    Electronic Resource
    Electronic Resource
    Lymphadenitis mimicking Hodgkin's disease (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 12 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A variant of lymphadenitis mimicking interfollicular Hodgkin's disease is described. The morphology, immunohistochemistry and clinical course of 25 cases are reported. The morphology is characterized by changes in the interfollicular region within a well-preserved lymph node architecture. These changes include variegated hyperplasia of the pulp with epithelioid cells, mature eosinophilic granulocytes and immunoblasts occasionally resembling Hodgkin cells. In contrast to Hodgkin's disease no typical Sternberg-Reed cells could be found. Immunohistochemically, neither positive reactions with Hodgkin cell markers (anti-CD15: LeuM1; 3C4; C3D-1) nor B-cell monoclonality could be detected. Transition to malignancy, in particular Hodgkin's disease, did not occur in our cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb01940.x
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  • 9
    Electronic Resource
    Electronic Resource
    Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: an immunohistochemical study on 75 patients (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To carry out an immunohistochemical study on bone marrow (BM) biopsy specimens in 75 patients with chronic myelogenous leukaemia (CML) on long-term STI571 therapy.Methods and results:  Sequential BM specimens taken at intervals of 21 ± 6 months were investigated by enzyme- and immunohistochemistry including proliferating cell nuclear antigen and apoptosis. Evaluation was performed either by semiquantitative scoring or by morphometry (CD61+ megakaryopoiesis). In 41 patients with chronic phase CML, treatment resulted in a significant decrease in cellularity and neutrophil granulopoiesis contrasting with an accumulation of erythroid precursor cells. Morphometry showed a reduction of abnormal micromegakaryocytes consistent with normalization. Regression of myelofibrosis was identified in eight of 15 patients, whereas progression occurred in 17 patients; mostly in those with acceleration and blastic crisis. The increased post-treatment incidence of reactive lymphoid nodules was remarkable. Myeloblasts, CD34+ progenitors and immature myelomonocytic cells initially decreased, but recurred in 14 patients who later developed a relapse. STI571 exerted an inhibitory effect on cell proliferation associated with enhanced apoptosis in responding patients.Conclusion:  Long-term treatment with STI571 exerts pronounced changes on BM histopathology that not only involve haematopoiesis and stromal constituents, but also proliferation and apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02119.x
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  • 10
    Electronic Resource
    Electronic Resource
    Monoclonality and polyclonality of plasma cells in Castleman's disease of the plasma cell variant (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Castleman's disease of the plasma cell variant observed in 21 patients was investigated morphologically and by immunohistochemistry. The male to female ratio was 2.5:1. The age ranged from 18 to 71 years (mean age 47.6 years). Histologically, the lesions were characterized by numerous, evenly distributed germinal centres ranging from large hyperplastic to small hyaline-vascular types with moderate to extensive sheets of plasma cells in between. In all cases with generalized lymph node enlargement dilated sinuses could be found. Immunohistochemical studies demonstrated a polyclonal plasma cell population in 11 of 18 lesions. Seven lesions contained a monoclonal plasma cell population, five with IgG/lambda and two with IgA/lambda; clinically, two of these patients had generalized lymphadenopathy; in none could manifestation of a plasmacytoma be found outside the lymph node lesion: only two of the seven patients exhibited a paraproteinaemia (IgG/lambda and IgA/lambda, respectively) corresponding to the Ig type of the proliferated plasma cells. Six patients with polyclonal lesions had constitutional symptoms such as fever, anaemia, polyclonal hypergamma-globulinaemia; one of these six patients manifested symptoms consistent with a diagnosis of Takatsuki syndrome. The monoclonal plasma cell type of Castleman's disease did not progress to a generalized disease. This monoclonal variant may be a lymph node-based type of benign monoclonal gammopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb02110.x
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