ISSN:
0001-1541
Keywords:
Chemistry
;
Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
An approach is presented for modeling the effects of temperature and pH on the solubility of amino acids in water. The amino acids studied are alanine, amino-butyric acid, glycine, hydroxy-proline, proline, serine, threonine, and valine. The data employed are activity coefficients and solubilities of the amino acids in neutral water and the dissociation constants for the various amino-acid ionization reactions. Activity coefficients are correlated with the modified UNIFAC group contribution model and with new glycine and proline groups being introduced.A similar approach is presented for modeling the solubilities of certain antibiotics in mixed nonaqueous solvents. Fusion temperature data and solubilities of the antibiotics in pure organic solvents are used to deduce modified UNIFAC energy interaction parameters between new large antibiotic groups and the standard alkane (CH2), alcohol (OH), aromat (ACH), and ester (CCOO) groups.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aic.690360303
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