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  • 1
    ISSN: 1432-2307
    Keywords: Osteosarcoma ; Neoadjuvant chemotherapy ; Morphometry ; Nuclear size ; Nuclear polymorphism ; Chondroblastic ground substance ; Osteoblastic ground substance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Osteosarcomas may show variable differentiation. They are divided into osteoblastic, chondroblastic and fibroblastic subgroups depending on their dominant histological differentiation. The pattern of histological differentiation of osteosarcoma is supposed to have an influence on the response to chemotherapy and in this study the relationship between the differentiation of the tumours and response to chemotherapy was examined in 22 osteosarcomas. For this purpose the nuclear size of tumour cells was determined on imprints and the area of the different ground substances on tumour sections after undecalcified preparation. Tumours with little nuclear polymorphism and those with an area of chondroblastic ground substance of more than 20% in the biopsy showed a poor response to chemotherapy. We conclude from our results that lack of nuclear polymorphism and in particular a large area of chondroblastic ground substances in the biopsy, can be regarded as an unfavourable prognostic factor in the response to primary chemotherapy. A comparison of the area of chondroblastic ground substance in biopsy and resection material proves that the biopsy delivers a representative view of the total area of chondroblastic ground substance for the groups of responder and non-responder. Patients with a large amount of chondroblastic ground substance in the biopsy probably require more aggressive chemotherapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 12 (1993), S. 1-18 
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Integral equations which contain as kernels fundamental solutions of differential operators defined on Riemann surfaces and spaces can be used advantageously for the treatment of boundary value problems when the domains have slits or cracks or overlapping parts. The present paper shows that a close relationship exists between this type of fundamental solutions of the plane potential operator and well-known series representations of harmonic functions on sectors. It turns out that, if a fundamental solution on a Riemann surface with an “optimal” number of sheets is chosen, several kernels in integral equations of the second kind for the potential problem vanish on the flanks of a sector. As a consequence, a potential problem on a domain with a corner can be formulated as an integral equation not taken over the whole boundary but only over a part of the boundary which does not contain the neighbourhood of the corner. The results apply also to slits since a slit is a corner with an aperture angle equal to 2π.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of elasticity 34 (1994), S. 23-44 
    ISSN: 1573-2681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Fundamental solutions of the differential operators for the potential problem and the elastostatic problem are established. They are not defined on the ordinary three-dimensional space as the classical 1/R solution and Kelvin's solution but on Riemann spaces with circular branch lines and a finite as well as an infinite number of sheets. The solutions can be used as the kernels of boundary integral equations. Equations of this type should be useful for the determination of displacements and stresses in elastic bodies with slits and cracks of certain shapes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 7 (1967), S. 47-48 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 713-729 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A characteristic feature of the variational functionals for several boundary value problems in polar co-ordinates is the fact that one independent variable occurs explicitly in the denominator. Therefore, the coefficients of the finite element equations for sectors of circular ring shaped elements are not constants but functions of the distance of the elements from the origin of co-ordinates.1 We name them coefficient functions. In order to show the particular aspects of the calculations in terms of polar co-ordinates we deal here with the solution of the torsion problem by bilinear and bicubic Hermitian interpolation.The finite element equations are arranged according to Schaefer2 in the form of block which can easily be transformed into ‘stars’3 or molecules4,5 similar to those used in finite difference methods. The origin of co-ordinates requires a special consideration, firstly because of the coincidence of several nodes at that point and secondly because of the divergent behaviour of some coefficient functions. It turns out to be advantageous for the numerical calculations to expand the coefficient functions in power series. Besides, the expansions are required to deduce the equations for rectangular elements by limiting processes. The twisting moments and shearing stresses calculated for several cross sections illustrate the numerical suitability of the method. The finite element values are compared partly with exact solutions and partly with experimental results obtained by a moiré method using Prandtl's soap film analogy.6 Finally it is shown how the accuracy of the finite element values can be improved by the Richardson extrapolation7.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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