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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 147 (1988), S. 350-355 
    ISSN: 1432-1076
    Keywords: Knemometry ; Human growth ; Growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cross-sectional and longitudinal studies of human growth have revealed almost every detail of the typical human growth pattern. Yet, the description of this pattern is still limited to the traditional vocabulary of “growth rates”, i.e. height or length differences divided by certain time intervals such as months or years. Almost no information is yet available on finer details of this pattern. This review concerns the existing experimental and clinical data collected by a novel and non-invasive technique of accurate lower leg length measurment named “knemometry” that has been used for the study of short-term growth. This technique estimates the distance between heel and knee of the sitting child with an accuracy (technical error) of 0.09–0.16 mm. Several authors have presented evidence that lower leg growth is non-linear. There is not only a marked day-to-day variation of the lower leg length which far exceeds the error of the measurement itself, but there is also a characteristic up-and-down pattern of lower leg growth consisting of sharp growth spurts (“mini-growth-spurts”) alternating with periods of decreased growth velocity every 30–55 days in 45 out of 73 healthy children. This patter can be visualized by the calculation of “mean daily lower leg growth velocities”, an approach that gives information on the kinetic properties of the growth process. In spite of much initial criticism, knemometry has opened a fascinating new dimension of the physiology of human growth and provided finer details of growth than hitherto obtainable by conventional techniques of growth measurement.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 146 (1987), S. 561-564 
    ISSN: 1432-1076
    Keywords: Anorexia nervosa ; Growth ; Knemometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently a novel and non-invasive technique of lower leg length measurement (knemometry) was introduced. The method estimates the distance between heel and knee in the sitting child with an accuracy of 0.09 mm(SD). Two female patients with anorexia nervosa, aged 14:4 and 13:7 years, weighing minus 27 and minus 38% of normal weight for age, were measured repeatedly with this method within periods of 72 and 129 days during hospitalization und up to 133 days thereafter. During the first 40 days of hospitalization, patient 1 was measured 30 times and showed significant shrinkage of the lower leg length of −0.040 mm/day (P〈0.001). Over the remainder of her hospital stay her mean lower leg length increment still was much less (+0.036 mm/day) than that expected just by increase of soft tissue due to rapid weight gain (+0.126 kg/day). The second patient also showed significant shrinkage of lower leg length during a 4 month period after discharge from the hospital (−0.009 mm/day,P〈0.01). This is the first demonstration of long term lower leg shrinkage in children. Its origin remains unclear, but this shrinkage is clearly distinct from either arbitrary changes of lower leg length due to errors of measurement or changes of body diameters due to temporary alterations of soft tissue (i.e. during periods of weight loss). We speculate that progressive atrophic changes of the epiphyseal plates still open in both patients may account for the observed long term shrinkage of lower leg length.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1989), S. 14-17 
    ISSN: 1432-1076
    Keywords: Tall girls ; Knemometry ; Proportionality of growth ; Growth ; Oestrogen treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the differential inhibitory effects of conjugated oestrogens on lower leg length and standing height increments in 17 excessively tall girls compared to a control group of 17 tall healthy untreated girls. Standing height, lower leg length and body weight were recorded at weekly or monthly intervals. Standing height velocity dropped from 150 μm/day to 122 μm/day, whereas daily weight gain increased from 17 to 48 g/day during oestrogen treatment. The oestrogen induced decrease of standing height velocity could be explained by a marked inhibition of lower leg growth velocity from 42 μm/day to 30 μm/day (native data) or 35 μm/day to 8 μm/day (data corrected for weight gain) (P〈0.001), whereas no differences of trunk growth velocity could be detected. Thus, the findings strongly suggest that pharmacological doses of oestrogens only affect epiphyseal growth.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 25 (1986), S. 97 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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