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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 36 (1964), S. 1155-1156 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 107 (1976), S. 343-351 
    ISSN: 1432-072X
    Keywords: Myxococcus ; Gliding bacteria ; Fimbriae ; Myxospores ; Fruiting bodies ; Cyclic AMP ; Pattern recognition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. Myxococcus xanthus B and M. virescens V2 were compared with a view to establishing the control of their morphogenetic cycles. Both organisms are typical myxococci and on solid media with low concentrations of nutrient they form fruiting bodies, within which vegetative cells convert to myxospores. Ultrathin sections of vegetative M. virescens resembled those of M. xanthus and contained prominent heavily stained bodies, presumed to be polyphosphate granules. Shadowed preparations showed fimbriae associated with M. xanthus but not with M. virescens. 2. M. xanthus B converted to myxospores in liquid medium in response to certain alcohols. M. virescens V2 produced phase-refractile spheres, which were not viable and had an unusual ultrastructure. 3. The distributions of fruiting bodies on solid media containing 0.02% Casitone were recorded for the two species and were compared with a Poisson distribution. Cells responded to differences in cell density in a manner suggestive of a response to a chemotactic attractant. Cells growing vegetatively and also cells forming fruiting bodies produced 3′,5′-cyclic adenosine monophosphate (cAMP) as measured by the incorporation of exogeneous [3H] adenosine into cAMP. 4. The significance of these findings for theories of fruiting body formation are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 781-784 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BOVINE pancreatic ribonuclease (RNase) is the only enzyme the primary structure of which is known1. A great deal of work has been done on the secondary and tertiary structure of this protein, but it is not possible to make any definite formulation of the conformation in aqueous solution2. In fact, ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 68 (1964), S. 1842-1852 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 80 (1983), S. 249-253 
    ISSN: 1432-2072
    Keywords: Amitriptyline ; Nortriptyline ; Plasma drug levels ; First pass metabolism ; Metabolite pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A single intramuscular (IM) dose of 50 mg amitriptyline (AT) was given to each of two healthy subjects who had previously taken three oral doses of AT tablets. The concentration-time curves of plasma nortriptyline (NT) arising from IMAT were fitted by computer to an equation based on the assumptions that NT is produced at a rate proportional to plasma AT concentration and is eliminated at a rate proportional to plasma NT concentration. The total amount of systemic NT produced was approximately equal for IM and oral AT doses, suggesting that the hepatic elimination of a given quantity of AT produces a constant amount of systemic NT, whether the AT is metabolised in the first pass or from the systemic circulation. This conclusion is supported by analysis of the time course of plasma NT concentration arising from oral AT doses. A large early production had previously been demonstrated and attributed to first-pass metabolism. The proportion of each oral AT dose eliminated in the first pass could now be estimated. values ranged from 51% to 70% and were approximately equal to the proportion of the total NT apparently formed in the first pass.
    Type of Medium: Electronic Resource
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