ISSN:
1437-160X
Keywords:
Macrophages
;
Gout tophi
;
Rheumatoid nodules
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evidence suggests that both macrophage and granulocyte populations continuously migrate towards, and are progressively incorporated into, the necrotic centres. These observations indicate that chemotactic activity in rheumatoid nodules is at a higher level than in gout tophi, or that the rheumatoid mononuclear phagocyte is more responsive to such stimuli.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00541376
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