ISSN:
1432-1351
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary 1. The success-rate of a conditioned response in goldfish was tested as a function of time after single additions of n-butanol and n-hexanol at different concentrations. 2. The same response, also tested as a function of time, was made during the approach to a final concentration of 15 mM n-butanol by one, two, three or six equal concentration steps. 3. Following a step increase in alcohol concentration, the initial conditioned response success-rate decreased (except for the step 0–2.5 mM of n-butanol) and was related both to the initial concentration and to the size of the step. 4. Recovery from decreased success-rates was observed for final concentrations of less than 15 mM n-butanol (by step) and 1.06 mM hexanol. The recovery was almost complete for the lower final concentrations, but only partial for 12.5 and 15.00 mM butanol. After single steps to a final concentration of 15 mM butanol there was no evidence of recovery by 5 h. Concentrations of 20 mM butanol, 1.35 mM hexanol produced fully anaesthetised fish. 5. The uptake of n-butanol in the brain of the fish was measured as a function of time following step changes in concentration from 0–10, 0–15 and 0–20 mM butanol. 6. A set of ‘dose response’ curves relating the conditioned response success-rate and brain concentration were calculated at different times from the above data; these show a shift to the right with increasing time. Thus, goldfish show the phenomenon of acute tolerance to n-butanol and n-hexanol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00605476
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