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  • 1
    Digitale Medien
    Digitale Medien
    Neuronal Ganglioside Increases Dependent on the Neuron-Glia Interaction in Primary Culture (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Dissociated neuronal cells from rat embryonic hemispheres were cultivated on astroglial layers. The increase in ganglioside content of the cocultures was more rapid than that of neuronal cultures seeded on polylysine surfaces for the first 24 h, and the extent of the increase was greater 7 days after inoculation, probably because of interaction between the preformed astroglial layers and the neuronal cells in vitro. The promoted expression of the a-pathway gangliosides, GM1 and GD la, was recognized by TLC and the increase in GM 1 was immunologically ascertained. The incorporation of 3H-labeled N-acetyl-D-mannosamine into GD3 and b-series gangliosides was elevated for the first 24 h. However, cocultures in which there was no contact between neuronal cells and the astroglial sheet showed no appreciable increase in incorporation. Thus, cell surface changes were induced at the membrane glycolipid level in the neuronal cells by contact with astroglial layers. The synthesis and expression of neuronal gangliosides are discussed in relation to the onset of neuron-glia interaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb09417.x
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  • 2
    Digitale Medien
    Digitale Medien
    CHANGES IN THE AMMONIA AND GLUTAMINE CONTENT OF THE RATBRAIN INDUCED BY ELECTRIC SHOCK (1958)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 2 (1958), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1958.tb12378.x
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  • 3
    Digitale Medien
    Digitale Medien
    Active Transport of γ-Aminobutyric Acid in Brain Cortex Slices, with Special Reference to Phosphorus-32 Turnover of Phospholipids in Cytoplasmic Particulates (1960)
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 474-475 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] If y-aminobutyric acid, a neutral amino-acid, which has an important effect on nervous functions, was present in the medium in the concentration of 5 mM instead of glutamate, it also accumulated actively in the brain slices depending upon energy-yielding processes (Table 1). In this case, however, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/186474a0
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  • 4
    Digitale Medien
    Digitale Medien
    Differences in ME-LI and VIP-LI in discrete brain regions of seizure-naive and seizure-experienced El mice (1988)
    Springer
    Neurochemical research 13 (1988), S. 983-988 
    Details
    ISSN: 1573-6903
    Schlagwort(e): El mouse ; seizure ; met-enkephalin ; vasoactive intestinal polypeptide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In an attempt to elucidate the relationship between endogenous methionine-enkephalin (ME) and vasoactive intestinal polypeptide (VIP) with generalized seizures, we determined regional brain levels of ME-like and VIP-like immunoreactivity (ME-LI and VIP-LI) in El mice during and after seizures induced by repeated tossing stimulation. The levels of ME-LI in the striatum and hippocampus of seizure-naive El mice (El−) were lower than those of the control ddY mice, the mother strain of El mice. Conversely, the level of VIP-LI in the medulla oblongata and pons of El− was higher than that of ddY mice. The level of ME-LI in the striatum of seizure-experienced El mice (El+) killed 96 hours after three consecutive seizures was high, while levels of VIP-LI in the striatum and hypothalamus were low, in comparison to those of El− mice. A detailed time-course study revealed that seizures in El mice caused (1) significant decreases in levels of ME-LI in the striatum and hippocampus during seizures, (2) a significant decrease of VIP-LI content in the striatum 3 hours after seizures, and (3) a significant increase in hypothalamic VIP-LI 9 hours after seizures. These observations suggest that ME and VIP may play some role in El mouse seizures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00970772
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  • 5
    Digitale Medien
    Digitale Medien
    Effects of hyperphenylalaninemia in the fetal stage on the postnatal development of fetal rat brain (1985)
    Springer
    Neurochemical research 10 (1985), S. 1071-1081 
    Details
    ISSN: 1573-6903
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of exposure at different prenatal stages to maternal hyperphenylalaninemia (HyPhe) on the somatic and neurological development of fetuses in rats was studied, with special respect to the change of relevant enzyme activities in the brain. While evident somatic damage was found only in the fetuses exposed to maternal HyPhe at a last stage of gestation, distinct mental retardation seemingly due to some irreversible damage to the brain was observed in all the treated fetuses regardless of the timing of exposure, and a significantly reduced activity of 2′, 3′-cyclic nucleotide 3′-phosphohydrolase (CNPase), a marker enzyme of myelin, was confirmed in the mantle region of the brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00965882
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