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  • 1
    Electronic Resource
    Electronic Resource
    Decreased Phosphorylation Levels of TrkB Neurotrophin Receptor in the Spinal Cords from Patients with Amyotrophic Lateral Sclerosis (2000)
    Springer
    Neurochemical research 25 (2000), S. 239-245 
    Details
    ISSN: 1573-6903
    Keywords: TrkB ; tyrosine kinase ; brain-derived neurotrophic factor (BDNF) ; phosphotyrosine ; amyotrophic lateral sclerosis (ALS)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of specific populations of cranial and spinal motor neurons. In this study, we examined the expression of the high affinity functional receptor for BDNF, TrkB, and assessed the functional state of TrkB by examining the level of phosphorylation on tyrosine residues in ALS spinal cords. The data showed that TrkB-immunoprecipitates prepared from cell-free lysates of ALS spinal cords by use of an anti-TrkB antibody contained much more TrkB protein than from controls. These TrkB proteins expressed in ALS spinal cords, however, are much less phosphorylated on tyrosine residues than those of controls. Moreover, RT-PCR analysis of TrkB mRNA in ALS spinal cords demonstrated that the expression of Trk B mRNA is also upregulated in ALS spinal cords compared with those of controls. These data strongly suggest that there exists an abnormality in TrkB-mediated intracellular signaling in ALS spinal cords and shed a light on the possibility of the therapeutic intervention by normalizing this intracellular signaling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007575504321
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  • 2
    Electronic Resource
    Electronic Resource
    Absence of expression of OKT8 antigen on cultured human, calf and rat oligodendrocytes (1983)
    [s.l.] : Nature Publishing Group
    Nature 301 (1983), S. 152-154 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mouse monoclonal antibodies which recognize human T lymphocytes (OKT3, OKT4, OKT6, OKT8) and monocytes and some null cells (OKM1) were obtained from Ortho Phar-maceuticals. Calf and rat oligodendrocytes were obtained by Percoll density gradient of trypsinized corpus callosum from young adult rats ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/301152a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The ultrastructure of isolated rat oligodendroglial cell cultures (1982)
    Springer
    Journal of neurocytology 11 (1982), S. 997-1008 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured rat oligodendrocytes were studied by transmission electron microscopy. Cells were identified by an immunocytochemical stain for galactocerebroside, a specific cell surface marker for oligodendroglial cells. Oligodendroglial cell perikarya contained numerous ribosomal rosettes, microtubules, prominent networks of cisternae of the Golgi apparatus and residual bodies. Glycogen and intermediate filaments were absent. Oligodendrocytes gave rise to numerous processes. Pentalaminar and heptalaminar profiles, consistent with tight and gap junctions, were seen between plasma membranes of processes and between perikarya and processes. The cell surface of processes showed numerous gross ruffles which stained for galactocerebroside. Similar membranous profiles appeared in the vicinity of oligodendroglial processes and suggested to us that the plasma membrane or certain of its components may be released into the medium. We concluded that cultured rat oligodendrocytes maintain many similarities with oligodendrocytesin situ and, therefore, are valid models for morphologic, physiologic and biochemical studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01148313
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    Paper (German National Licenses)
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