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  • 1
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 696-698 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The thioredoxin-related protein tryparedoxin I from Crithidia fasciculata has been crystallized using PEG 4000 as a precipitant. The enzyme forms long needle-shaped crystals which diffract to at least 1.7 Å. A native data set has been collected at the DESY synchrotron from a flash-frozen crystal at 90 K to 1.7 Å resolution. The data set shows that the crystals belong to the orthorhombic space group P212121 and have unit-cell parameters a = 37.94, b = 51.39, c = 71.46 Å. Tryparedoxin I is involved in a trypanothione-dependent peroxide metabolic pathway specific for trypanosomatids and may therefore be a suitable candidate for the design of drugs for the specific treatment of a variety of important tropical diseases caused by these parasites.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Tachyarrhythmie ; Kardioverter Defibrillator ; Psychogene Triggerung ; Emotional-kognitive Faktoren ; Key words Tachyarrhythmia ; Implantable cardioverter defibrillator ; Emotional stress ; Psychic arousal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Tachyarrhytmias often occur during increased emotional arousal or mental excitation. The implantable cardioverter defibrillator (ICD) allows the exact documentation of arrhythmic episodes and their time of onset. Therefore, the type of arrhythmia can be differentiated as well as the circumstances surrounding the event. These features allow the assessment of possible psychic arrhythmogenic factors in the natural environment. We analyzed the ICD-protocols of three male patients (in ages between 60 and 68), whose devices had successfully terminated a ventricular tachycardia and compared the onset of the episodes with the patients' detailed descriptions of the corresponding life situations. The analysis of the circumstances at the time of arrhythmia-onset revealed a relationship between the occurrence of life-threatening arrhythmias in natural environment and emotional stress. The stressors could be defined as situations of increased vulnerability leading to sympathetic excitation. The induction of tachyarrhythmia was promoted in case 1 by acute psychic distress (public speaking), by the increasing panic-attack-like vicious circle of the cognitive anticipation of an unfavorable outcome (case 2), and an adverse anger reaction superimposed on persistent feelings of help- and hopelessness (case 3). These findings are in line with several experimental and epidemiological studies providing evidence for a relationship between psychic arousal and the induction of tachyarrhythmias. The knowledge of emotional and mental factors that function as a trigger for arrhythmias may lead to new therapeutic approaches in the prevention of sudden cardiac death.
    Notes: Zusammenfassung Tachyarrhythmien treten häufig während erhöhter psychischer Erregung auf. Bei Patienten, bei denen ein Kardioverter Defibrillator (ICD) implantiert wurde, lassen sich arrhythmische Episoden und deren Onset-Zeitpunkt exakt aufzeichnen und erlauben so einerseits die Differenzierung der aufgetretenen Rhythmusstörung und andererseits eine detailliertere Analyse der situativen Umstände und möglicher an der Auslösung beteiligter psychischer Komponenten. In der vorliegenden einzelfallbezogenen Studie wurden bei 3 männlichen Patienten im Alter zwischen 60 und 68 Jahren, bei denen der ICD erfolgreich eine ventrikuläre Tachykardie terminiert hatte, die ICD-Protokolle und die damit korrespondierenden Patientenaussagen analysiert. Die Analyse der akuten Onset-Bedingungen konnte ausgeprägte Zusammenhänge zwischen lebensbedrohlichen Herzrhythmusstörungen in natürlicher Umgebung und emotionalen Stressoren aufdecken. Als Stressoren wurden unterschieden eine vulnerable Situation, die eine psychogene Triggerung maligner Arrhythmien bewirkte (Fall 1); eine Panikepisoden-ähnliche Erwartungsspannung (Fall 2) sowie eine aversive Ärgerreaktion, die auf dem Boden eines andauernden Zustandes von Hilf- und Ausweglosigkeit (Fall 3) einen besonders potenten sympathiko-exzitatorischen Stimulus darstellt. Dieses Ergebnis deckt sich mit einer Reihe von laborexperimentellen und epidemiologischen Studien, die einen Zusammenhang zwischen psychischer Erregung und der Entstehung von Tachyarrhythmien belegen. Die Berücksichtigung emotional-kognitiver Faktoren bei der Arrhythmogenese könnte ein Beitrag bei der Therapie zur Prävention des plötzlichen Herztodes werden.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 231 (1993), S. 303-307 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a new multipurpose method for corneal refractive surgery by using a focused excimer laser beam, which allows the application of a small, compact low-energy excimer laser. It is possible to ablate any area desired in the cornea without masking by scanning the focused beam. The ablation depths in freshly enucleated swine eyes were measured in relation to the number of laser pulses (at fixed fluence) and the pulse fluence at wavelengths λ = 248 nm and λ =193 nm. The irradiation conditions were investigated to obtain smooth ablation of the corneal material over an area of about 1 cm2. The experiments show that smooth ablation is obtained when the ratio of the excimer laser beam spot diameter on the corneal surface and the displacement for one scanning step is given by a whole number. A simple model based on rectangular beam profiles is presented to exemplify this.
    Type of Medium: Electronic Resource
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