Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats (1991)
    Springer
    Diabetologia 34 (1991), S. 81-85 
    Details
    ISSN: 1432-0428
    Keywords: Insulin resistance ; euglycaemic hyperinsulinaemic clamp ; offspring of streptozotocin-diabetic rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our previous work has suggested the presence of an insulin resistance in the adult offspring of streptozotocindiabetic pregnant rats. In this study we used the euglycaemic hyperinsulinaemic clamp technique with an isotope-dilution method to define and quantify this postulated insulin resistance in adult offspring of streptozotocin-diabetic rats. Under basal conditions, these rats had a lower body weight than control rats, but their glucose and insulin concentrations were normal. During the hyperinsulinaemic clamp, the steady-state glucose infusion rate was significantly lower in the offspring of streptozotocin-diabetic rats than in both ageand weight-matched controls, indicating insulin resistance. Basal peripheral tissue glucose utilization was normal in the offspring of streptozotocin-diabetic rats, but the dose-response curve was shifted to the right: insulin concentrations causing half-maximal stimulation of glucose utilization were increased by about 60% in the offspring of diabetic rats; the maximal stimulation of glucose utilization, however, was unaltered. Basal hepatic glucose production was normal, but again, half-maximal suppression of glucose production occurred at insulin concentrations 50% higher than in control rats; in addition, the maximal suppression of glucose production was significantly decreased, even at insulin concentrations of 5700 μU/ml. These data are evidence for an insulin resistance in the adult offspring of streptozotocin-diabetic rats, characterized by: (1) a decreased insulin sensitivity by peripheral glucose-utilizing tissues, and, (2) a decreased sensitivity and responsiveness of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500377
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring (1999)
    Springer
    Diabetologia 42 (1999), S. 81-89 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin dependent diabetes ; rat offspring ; vascular function ; endothelium ; streptozotocin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Severe diabetes in pregnant rats produces persistent metabolic consequences in adult offspring. This study investigated whether diabetes in pregnant rats could also lead to cardiovascular abnormalities in the adult offspring. Blood pressure, heart rate and in vitro vascular reactivity of small arteries were evaluated in female adult offspring of control rats and of rats rendered diabetic with streptozotocin. Rise in blood pressures were similar in both groups of offspring but heart rate was lower in the diabetic offspring (p 〈 0.05). The rise in blood pressure associated with infusion of a nitric oxide synthase inhibitor was similar in both groups, but the associated decrease in heart rate was more pronounced in diabetic offspring (p 〈 0.01). Small mesenteric arteries from this group showed enhanced sensitivity to noradrenaline (p 〈 0.05) and abnormal endothelium-dependent relaxation to acetylcholine (p 〈 0.01) and bradykinin (p 〈 0.05). Reduction in acetylcholine induced relaxation, reflected reduced synthesis of nitric oxide or a cyclooxygenase product and was not attributable to an endothelium-derived hyperpolarizing factor. Sensitivity to exogenous nitric oxide was normal. A subgroup of pups born to diabetic dams were suckled by control maternal dams and a subgroup of those born to controls by diabetic dams. Suckling was an important determinant of impaired growth; offspring of diabetic rats suckled by their own mother and those of control rats by diabetic dams showed impaired growth rates whereas growth of offspring of diabetic rats suckled by control dams paralleled those of control rats suckled by their own mother. [Diabetologia (1999) 42: 81–89]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051117
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    An analysis of some inhibitory mechanisms in the spinal cord of the frog (Xenopus laevis) (1968)
    Springer
    Pflügers Archiv 303 (1968), S. 287-310 
    Details
    ISSN: 1432-2013
    Keywords: Frog ; Inhibition ; Presynaptic ; Postsynaptic ; Recurrent ; Frosch ; Hemmung ; Präsynaptisch ; Postsynaptisch ; Rekurente Hemmung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three mechanisms of inhibition in the spinal cord of frogs (Xenopus laevis) were investigated. Motoneuron excitability was assessed by the method of monosynaptic testing. The study revealed that orthodromic as well as antidromic volleys initiate central inhibitory phenomena. 1. Orthodromic volleys result in two different inhibitory processes. (i) Postsynaptic inhibition of motoneurons. The latency and time course of this inhibition is compatible with the view that the inhibitory pathway contains at least on inhibitory interneuron and is therefore comparable to the simplest inhibitory pathway of the mammalian spinal cord. (ii) Presynaptic inhibition of polysynaptic excitatory pathways. The time course of this mode of inhibition is identical with the time course of orthodromically elicited dorsal root potentials. Both postsynaptic and presynaptic inhibition by dorsal root volleys are similar to the corresponding processes in mammals. This presynaptic inhibition, however, does not affect monosynaptic reflex arcs. The demonstration of their existence is complicated in the frog by the occurrence of a powerful facilitatory component in a dorsal root volley. 2. Antidromic or recurrent volleys inhibit monosynaptic reflexes according to the same time course as antidromically elicited dorsal root potentials. The presynaptic location of the inhibition in the frog is confirmed by: (i) the finding that testing from descending motor pathways failed to show the inhibition and (ii) its subsistance under the influence of strychnine. The time course of recurrent inhibition and probably integrative value are comparable in frogs and in mammals. The mechanism underlying this inhibition in the frog, however, is very different from the postsynaptic Renshaw mechanism of the mammalian spinal cord. These observations show that the same result (recurrent inhibition) is obtained by different means in the two classes of vertebrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596387
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Disinhibition processes in the cord of the spinal frog (Xenopus laevis) (1968)
    Springer
    Pflügers Archiv 303 (1968), S. 311-323 
    Details
    ISSN: 1432-2013
    Keywords: Frog ; Disinhibition ; Presynaptic ; Postsynaptic Disinhibition ; Frosch ; Aufhebung der Hemmung ; Präsynaptisch ; Postsynaptische Hemmung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Spinal frogs (Xenopus laevis) were used to study the interaction between orthodromic (postsynaptic) and recurrent (presynaptic) inhibition. 2. It was found that under special conditions the inhibitory component of a dorsal root volley was disinhibited by a recurrent volley and also that orthodromic volleys decreased and sometimes almost abolished recurrent inhibition. 3. The results constitute an example of a disinhibition of phasic phenomena and in addition, present a clear example of interaction between, presynaptic and postsynaptic inhibition. 4. The pathways postulated to account for both types of disinhibition are presented in a summarizing diagram.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596388
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...