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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 29 (1974), S. 251-262 
    ISSN: 1432-0533
    Keywords: Polymyositis ; Ultrastructure ; Histiocytes ; Birbeck Granules ; Macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A fatal case of polymyositis in a young female is presented. Two muscle biopsies obtained before and after treatment with large doses of steroids, as well as autopsy tissue, demonstrated widespread degeneration of myofibres associated with cytoplasmic tuboreticular structures resembling paramyxovirus nucleocapsids in capillary endothelial cells and fibroblasts. Aggregates of spherical particles and “simple and granular” nuclear bodies suggested a virus-related or associated etiologic agent. In addition, interstitial cells of mesenchymal origin, probably related to macrophages or histiocytes were present. These contained numerous rodlike profiles or phagolysosomal bodies which resembled “Birbeck” granules. Inflammatory response was very scant. It would appear that polymyositis probably represents a primary reaction to antigemic substances and a morphologic manifestation of altered host macrophage response.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-9104
    Keywords: Gamma irradiation ; Mycotoxins in grains
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The effects of gamma irradiation on degradation of aflatoxin B1 in wheat, corn, and soybeans and of T-2 toxin in wheat, deoxynivalenol (DON) in soybeans, and zearalenone in corn at 9, 13, and 17% moisture were studied. Radiation doses of 5, 7.5, 10 or 20 kGy were applied to spiked grain samples, and the residual toxins were measured using an enzyme linked immunosorbent assay (ELISA). Irradiation doses of up to 20 kGy did not significantly affect aflatoxin B1 in any of the three grains, but significant reductions occurred in T-2 toxin, DON, and zearalenone concentration at doses of 10 or 20 kGy and in T-2 toxin at the 7.5 kGy dose. Two-way analysis of variance with Tukey's Multiple Range Test showed no significant interaction between radiation dose and grain moisture level. Irradiation of the ground grains at doses higher than 5 kGy resulted in small, but significant, losses of lysine in corn (only at 7.5 kGy), wheat, and soybeans, and methionine was reduced in wheat and corn samples. In some cases, phenylalanine decreased in corn and wheat, and histidine levels in wheat were reduced in samples receiving 7.5 kGy of irradiation. Other essential amino acids were not affected significantly by irradiation.
    Type of Medium: Electronic Resource
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