ISSN:
1432-0584
Keywords:
Key words Down syndrome
;
Transient abnormal myelopoiesis
;
Apoptosis
;
bcl-2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Transient abnormal myelopoiesis (TAM) is a haematological complication found in Down syndrome. To determine the mechanisms of sustained proliferation of TAM cells, we studied the expression of apoptosis-related proteins, such as bcl-2, Fas (APO-1/CD95) and p-53, in peripheral blood cells from a new-born infant with Down syndrome and TAM. Using flow cytometry, peripheral blood mononuclear cells (PBMCs), consisting mostly of blast cells, showed marked expression of bcl-2 protein but not of Fas or p-53 products. DNA gel electrophoresis of PBMCs, cultured in the absence of serum factors, revealed no marked fragmentation. Our findings suggest that bcl-2 overexpression may be associated with prolonged cell survival of TAM cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002779900138
Permalink